pteroyln.
/ˈtɛrəʊɪl/, /ˈtɛrəʊʌɪl/, U.S. /ˈtɛroʊɪl/ Chemistry.
An acyl radical derived from pteroic acid. Usually attributive and as a formative element in chemical names, esp. of compounds related to folic acid which have a side chain consisting of a number of glutamate residues.Recorded earliest in pteroylglutamic adj.
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1946 R. B. Angier et al. in Science 31 May 669/1 For the compounds formed from p-aminobenzoic acid and p-aminobenzoyl-l(+)-glutamic acid, the names pteroic acid and pteroylglutamic acid are suggested.
1949 Science 14 Jan. 33/2 The activity of xanthopterin and pteroyl derivatives in accelerating the rate of cell proliferation in vitro..has been found to be greatly increased by the action of certain enzymes.
1970 R. Passmore & J. S. Robson Compan. Med. Stud. II. vii. 7/1 Folic acid in therapeutics means synthetic pteroylmonoglutamic acid but the term is sometimes used to embrace all naturally occurring substances with folic acid activity.
1992 Jrnl. Medicinal Chem. 35 1227 The synthesis of a novel series of gamma-substituted folic acid analogues, pteroyl-S-alkyl-DL-homocysteine (RS)-sulfoximines..is described.
2002 Bioorganic & Med. Chem. Lett. 12 2191/2 Unlike GCP II [glutamate carboxypeptidase II], a pteroyl group is essential for the strong binding of the inhibitor to FPGS compounds.
This is a new entry (OED Third Edition, September 2007; most recently modified version published online March 2022).
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n.1946