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单词 pyridostigmine
释义

pyridostigminen.

Brit. /ˌpɪrᵻdəʊˈstɪɡmiːn/, U.S. /ˈˌpɪrədoʊˈstɪɡˌmin/
Forms: 1900s– pyridostigmin, 1900s– pyridostigmine.
Origin: A borrowing from German. Etymon: German Pyridostigmin.
Etymology: < German Pyridostigmin (1953 or earlier) < pyrid- (in Pyridin pyridine n.) + -o- -o- connective + -stigmin (in Prostigmin Prostigmine n. (1931)).
Pharmacology.
More fully pyridostigmine bromide. A cholinesterase inhibitor structurally related to neostigmine but having a longer duration of action and fewer side effects, used in the treatment of myasthenia gravis, and also given to provide pre-exposure protection against nerve gases.Chemical name: 3-dimethylcarbamoyloxy-1-methylpyridinium bromide, C9H13BrN2O2.
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the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for myasthenia
Prostigmine1931
neostigmine1943
pyridostigmine1953
1953 Jrnl. Amer. Med. Assoc. 12 Sept. 175/1 Since 1948, a pyridine homologue of neostigmine (Pyridostigmine) was given a therapeutic trial in 23 patients with myasthenia gravis associated with pseudoparalysis.
1967 Anesthesiology 28 528 (title) Pyridostigmin (mestinon) as an antagonist of d-tubocurarine.
1993 Brit. Jrnl. Surg. 80 223/2 After operation frank myasthenia developed, initially requiring ventilation but responding well to pyridostigmine.
2000 L. Crane Ninth Day of Creation 423 Tulloch had urged funding for..an anti-nerve agent drug called pyridostigmine bromide, anticipating by six years the eventual conflict with Iraq.
This entry has been updated (OED Third Edition, December 2007; most recently modified version published online March 2022).
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n.1953
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