pyrogenn.

1844 G. Fownes Man. Elem. Chem. iv. 448 These phenomena present admirable illustrations of the production of pyrogen acids by the agency of heat.

1866–8 H. Watts Dict. Chem. IV. 759 Pyrogen, a name applied by Dumas to pyro-acids and other products of the action of heat on organic bodies.

1845 J. J. Lake in Polytechnic Rev. & Mag. Jan. 4 (title) On the nature of pyrogen (the electric fluid) and causes of combustion. [Note] The term Pyrogen is here applied to the electric fluid, because there appears to be a degree of indefiniteness in the terms electricity, electric fluid, &c.

1848 J. J. Lake in Lancet 23 Dec. 694/1 This experiment not only proves the existence of pyrogen, but also affords a clue to its identity.

1850 C. H. Peirce tr. J. A. Stöckhardt Princ. Chem. i. 137 Phosphorus and sulphur are especially characterized by their great inflammability; hence they may be called pyrogens, or fire-generators.

1872 Appletons' Jrnl. 14 Dec. 661/3 All the ‘imponderables’,..light, heat, electricity, magnetism, etc., are essentially one and the same, being interchangeable,..and all owing their origin to the same hidden ‘gen’, whether to be called photogen, or pyrogen, or electrogen, or kinogen, or something of the sort.

1888 Amer. Anthropologist 1 294 This invention was put on the market as a method of getting fire prior to 1832,..and it entered into competition with flint and steel, the phosphorus bottle, and the various pyrogens of that period.

1875 J. Burdon-Sanderson in Brit. Med. Jrnl. 13 Feb. 200/2 This must not be understood to mean that they were not at first in a state of decomposition, but simply that the pyrogen (as we may, for shortness, call it, whatever its chemical nature) is a product which is produced at an early stage in the septic process.

1955 Times 30 Aug. 4/3 We have now reached the stage where bacterial pyrogens in pure form can, with advantage, replace the older materials and methods for producing a general stimulation of the defence mechanisms of the body.

1973 Nature 16 Nov. 162/2 It is not known whether the malarial parasite produces a pyrogen, like bacteria, or whether the malarial fever results from destruction of red blood cells.

2000 J. Mann Murder, Magic, & Med. (rev. ed.) iv. 220 They then burst and release merozoites, which invade other erythrocytes, and pyrogens (chemical mediators of fever).

1937 Amer. Jrnl. Surg. 37 136 (title) A method for producing pyrogen-free water for intravenous therapy.

1982 Jrnl. Nucl. Med. 23 739 Use of this system results in the preparation of a sterile, pyrogen-free product suitable for human injection.

1998 Amer. Jrnl. Vet. Res. 59 153 Controls received pyrogen-free saline solution.