quinacrinen.

Brit.

/ˈkwɪnəkriːn/,

/ˈkwɪnəkrɪn/, U.S.

/ˈkwɪnəˌkrɪn/

Origin: Formed within English, by derivation. Etymons: quinine n., acridine n., -ine suffix⁵.

Etymology: < quin- (in quinine n.) + acr- (in acridine n.) + -ine suffix⁵. Compare French quinacrine (1936 or earlier).

Pharmacology and Biochemistry.

An antiprotozoal agent used esp. to treat malaria (originally) and giardiasis and also for histochemical staining.Chemical name: 3-chloro-7-methyl-9-(1-methyl-4-diethyl aminobutylamino)acridine; C₂₃H₃₀N₃OCl.The International Nonproprietary Name and British Approved Name (1996) for the compound is mepacrine.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for malaria

Plasmochin1926

Plasmoquine1926

atebrin1932

quinacrine1934

pamaquin1941

Paludrine1944

chloroquine1946

Resochin1946

proguanil1948

primaquine1949

hydroxychloroquine1951

pyrimethamine1952

mefloquine1974

qinghaosu1979

1934 Chem. Abstr. 28 3792 Quinacrine is chloro-2-diethylaminopentylamino-5-methoxy-7-acridine dihydrochloride.

1944 Jrnl. Amer. Med. Assoc. 5 Aug. 977/1 Quinacrine (atabrine) has proved to have all the antimalarial properties ascribed to quinine.

1960 C. Achebe No Longer at Ease xi. 105 He said the poor man must be suffering from malaria, and the next day he bought him a tube of quinacrine.

1975 F. C. Fraser & J. J. Nora Genetics of Man ii. 10/1 Quinacrine binds preferentially to certain regions of metaphase chromosomes to produce characteristic banding patterns (‘Q-bands’).

2001 Guardian 14 Aug. i. 5/7 Far wider human tests should be organised using the anti-malarial drug quinacrine, not widely administered in Britain since the 1970s although still used on a ‘named patient basis’ to combat conditions including giardia.

Compounds

C1. attributive, with reference to the use of quinacrine or quinacrine derivatives in histochemical staining.

quinacrine-stained adj.

ΚΠ

1970 Nature 6 June 961/2 (caption) A group of quinacrine-stained spermatozoa showing fluorescence.

1997 Amer. Jrnl. Physiol. 273 C1533 Granular fluorescence was observed in the quinacrine-stained macular sensory epithelium.

quinacrine staining n.

ΚΠ

1970 Nature 6 June 897/1 The quinacrine staining test shows up the number of Y chromosomes in a human interphase (non-dividing) cell.

2000 Arch. Androl. 44 47 There have been claims that quinacrine staining can falsely increase apparent Y-bearing sperm enrichment following certain separation procedures.

C2.

quinacrine mustard n. a nitrogen mustard derived from quinacrine, used as a fluorescent stain for chromosomes.

ΘΚΠ

the world > life > biology > laboratory analysis > material > [noun] > staining material

osmium tetroxide1869

picrocarmine1872

rose bengal1878

stain1880

erythrosin1884

Gram stain1884

vesuvin1885

Nile blue1888

pyronin1895

Janus green1898

counterstain1899

Nissl stain1899

Leishman stain1904

trypan blue1911

quinacrine mustard1957

1957 R. Jones et al. in Jrnl. Org. Chem. 22 783/2 We here wish to report on the conversion..of 2-methoxy-6,9-dichloroacridine to 2-methoxy-6-chloro-9-[4-bis(β-chloroethyl)-amino-1-methylbutylamino]acridine (quinacrine mustard).

1971 New Scientist 18 Mar. 606/1 When hamster and bean chromosomes were stained with..quinacrine mustard, and viewed with long wave-length ultraviolet light, the chromosomes fluoresced differently along their length.

2003 Mutation Res. 530 47 Here we demonstrate that caffeine and another xanthine, pentoxifylline,..effectively alleviate mutagenic action of polycyclic aromatic agents (exemplified by quinacrine mustard).

This entry has been updated (OED Third Edition, December 2007; most recently modified version published online March 2022).

单词	quinacrine
释义	quinacrinen. Brit. /ˈkwɪnəkriːn/, /ˈkwɪnəkrɪn/, U.S. /ˈkwɪnəˌkrɪn/ Origin: Formed within English, by derivation. Etymons: quinine n., acridine n., -ine suffix⁵. Etymology: < quin- (in quinine n.) + acr- (in acridine n.) + -ine suffix⁵. Compare French quinacrine (1936 or earlier). Pharmacology and Biochemistry. An antiprotozoal agent used esp. to treat malaria (originally) and giardiasis and also for histochemical staining.Chemical name: 3-chloro-7-methyl-9-(1-methyl-4-diethyl aminobutylamino)acridine; C₂₃H₃₀N₃OCl.The International Nonproprietary Name and British Approved Name (1996) for the compound is mepacrine. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for malaria Plasmochin1926 Plasmoquine1926 atebrin1932 quinacrine1934 pamaquin1941 Paludrine1944 chloroquine1946 Resochin1946 proguanil1948 primaquine1949 hydroxychloroquine1951 pyrimethamine1952 mefloquine1974 qinghaosu1979 1934 Chem. Abstr. 28 3792 Quinacrine is chloro-2-diethylaminopentylamino-5-methoxy-7-acridine dihydrochloride. 1944 Jrnl. Amer. Med. Assoc. 5 Aug. 977/1 Quinacrine (atabrine) has proved to have all the antimalarial properties ascribed to quinine. 1960 C. Achebe No Longer at Ease xi. 105 He said the poor man must be suffering from malaria, and the next day he bought him a tube of quinacrine. 1975 F. C. Fraser & J. J. Nora Genetics of Man ii. 10/1 Quinacrine binds preferentially to certain regions of metaphase chromosomes to produce characteristic banding patterns (‘Q-bands’). 2001 Guardian 14 Aug. i. 5/7 Far wider human tests should be organised using the anti-malarial drug quinacrine, not widely administered in Britain since the 1970s although still used on a ‘named patient basis’ to combat conditions including giardia. Compounds C1. attributive, with reference to the use of quinacrine or quinacrine derivatives in histochemical staining. quinacrine-stained adj. ΚΠ 1970 Nature 6 June 961/2 (caption) A group of quinacrine-stained spermatozoa showing fluorescence. 1997 Amer. Jrnl. Physiol. 273 C1533 Granular fluorescence was observed in the quinacrine-stained macular sensory epithelium. quinacrine staining n. ΚΠ 1970 Nature 6 June 897/1 The quinacrine staining test shows up the number of Y chromosomes in a human interphase (non-dividing) cell. 2000 Arch. Androl. 44 47 There have been claims that quinacrine staining can falsely increase apparent Y-bearing sperm enrichment following certain separation procedures. C2. quinacrine mustard n. a nitrogen mustard derived from quinacrine, used as a fluorescent stain for chromosomes. ΘΚΠ the world > life > biology > laboratory analysis > material > [noun] > staining material osmium tetroxide1869 picrocarmine1872 rose bengal1878 stain1880 erythrosin1884 Gram stain1884 vesuvin1885 Nile blue1888 pyronin1895 Janus green1898 counterstain1899 Nissl stain1899 Leishman stain1904 trypan blue1911 quinacrine mustard1957 1957 R. Jones et al. in Jrnl. Org. Chem. 22 783/2 We here wish to report on the conversion..of 2-methoxy-6,9-dichloroacridine to 2-methoxy-6-chloro-9-[4-bis(β-chloroethyl)-amino-1-methylbutylamino]acridine (quinacrine mustard). 1971 New Scientist 18 Mar. 606/1 When hamster and bean chromosomes were stained with..quinacrine mustard, and viewed with long wave-length ultraviolet light, the chromosomes fluoresced differently along their length. 2003 Mutation Res. 530 47 Here we demonstrate that caffeine and another xanthine, pentoxifylline,..effectively alleviate mutagenic action of polycyclic aromatic agents (exemplified by quinacrine mustard). This entry has been updated (OED Third Edition, December 2007; most recently modified version published online March 2022). < n.1934
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