resolvasen.
/rᵻˈzɒlveɪz/, U.S. /rəˈzɔlveɪz/, /riˈzɔlveɪz/, /rəˈzɑlveɪz/, /riˈzɑlveɪz/; see also -ase suffix. Biochemistry.
An enzyme which brings about the separation of two transposons contained in a cointegrate during the process of replicative transposition.
ΚΠ
1981 R. R. Reed in Cell 25 713/2 These results have led to the suggestion that the regulatory role of the tnpR product upon expression of the divergently transcribed tnpA and tnpR genes and its recombinational activity may both result from specific binding to a single site... To emphasize this major function, the tnpR protein has been renamed ‘resolvase’.
1983 J. R. S. Fincham Genetics x. 270 Reciprocal recombination, specifically catalysed in the recombination sequence of the transposon by the tpnR product (‘recombinase’ or ‘resolvase’), resolves the cointegrate into two separate plasmids.
1988 Nature 28 Apr. 862/1 Resolvase catalysed substantial relaxation of the mutant substrate into topoisomers of reduced negative superhelicity.
2004 Molecular Cell 16 127/1 Tn3 resolvase is a site-specific DNA recombinase.
This entry has been updated (OED Third Edition, March 2010; most recently modified version published online March 2022).
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n.1981