saralasinn.
/səˈraləsɪn/ Pharmacology.
A synthetic octapeptide which blocks the pressor action of hypertensin II, thereby reducing high blood pressures.
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the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for blood-pressure disorders > biological or synthetic
spironolactone1960
minoxidil1970
saralasin1974
1974 Lancet 28 Dec. 1535/1 Angiotensin-II blockade by the competitive antagonist sar1-ala8-angiotensin 11 (‘Saralasin’)... Blockade of angiotensin II with saralasin has been advocated.
1977 Lancet 24 Dec. 1317/1 Two types of renin-angiotensin inhibitor have been tested in renal hypertension—competitive antagonists of angiotensin II, such as saralasin, and inhibitors of the converting enzyme.
This entry has not yet been fully updated (first published 1982; most recently modified version published online June 2018).
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