α. 1900s– Schmidt reaction.
β. 1900s– Schmidt's reaction.
Schmidt reactionn.
/ˈʃmɪt rɪˌakʃn/, U.S. /ˈʃmɪt riˌækʃ(ə)n/ Chemistry.
A reaction in which a carbonyl group reacts with an azide in the presence of mineral acid to form a nitrile, amide, or amine, together with molecular nitrogen.The Schmidt reaction is a widely-used synthetic method whose products depend on the kind of carbonyl compound used. An aldehyde gives a mixture of a nitrile and a formyl derivative of an amide; a ketone gives an amide; and a fatty acid gives an amine.
ΘΚΠ
the world > matter > chemistry > organic chemistry > chemical processes or reactions > processes or reactions attributed to chemists > [noun] > others
Skraup1886
Friedel–Crafts1892
Schotten–Baumann method1895
Cannizzaro1897
Grignard('s) reaction1904
Liebermann–Burchard reaction1904
Raschig process1920
Fischer–Tropsch1933
Schmidt reaction1937
1936 Proc. Royal Soc. A. 154 54 The introduction of the Schmidt method leaves the Hofmann method of great historical interest but deprives it of importance for costly and delicate synthetic work.]
1937 Jrnl. Amer. Chem. Soc. 59 2658/1 Although the Schmidt reaction has been used in a few instances it has never been extensively studied.
1963 I. L. Finar Org. Chem. (ed. 4) I. ix. 178 Schmidt's reaction with acids is a modification of the Curtius reaction.
1976 A. Streitwieser & C. H. Heathcock Introd. Org. Chem. xxviii. 825 The Schmidt reaction may also be used for the synthesis of simple amino acids if it is applied to an alkylated malonic acid.
2010 Jrnl. Amer. Chem. Soc. 132 2530/1 We now show that intramolecular Schmidt reactions can be reliably steered toward bridged heterocycles containing orthoamides in high yields.
This entry has been updated (OED Third Edition, June 2019; most recently modified version published online March 2022).
<
n.1937