semi-conservativeadj.

Etymology: semi- prefix 1a.Previous versions of the OED give the stress as: ˌsemi-conˈservative.

Biochemistry.

Of the replication of nucleic acid: such that one complete strand of each double helix is directly derived from its parent. The term was originally proposed (see quot. 1957²) to designate a class of models of the replication of DNA; it is now accepted that its true mechanism of replication falls in this class.

ΚΠ

1957 Delbruck & Stent in McElroy & Glass Chem. Basis of Heredity 707 The considerable number of proposed schemes may be divided into three general classes as conservative, semi-conservative, and dispersive.

1957 Delbruck & Stent in McElroy & Glass Chem. Basis of Heredity 709 Semi-conservative mechanisms are those which conserve the atomic identity of single chains of the parental DNA duplex, although effecting a permanent separation of the two chains from each other in the course of replication.

1970 Nature 7 Nov. 522/1 There is good evidence that DNA replication is semi-conservative and involves separation of the two strands which then act as templates.

1976 P. Collard Devel. Microbiol. viii. 106 Semi-conservative replication thus provided a possible answer to the riddle of the stability of the genome from generation to generation.

Derivatives

ˌsemiconˈservatively adv.

ΚΠ

1966 Jrnl. Molecular Biol. 15 372 Since all the DNA is replicated semiconservatively..such a segregation pattern could arise most simply if every chromosome contained all its DNA within a single molecule.

1979 Nature 3 May 75/2 pBR322 DNA replicates semiconservatively and completely in a crude lysate of E. coli.

This entry has not yet been fully updated (first published 1986; most recently modified version published online June 2019).

单词	semi-conservative
释义	semi-conservativeadj. Etymology: semi- prefix 1a.Previous versions of the OED give the stress as: ˌsemi-conˈservative. Biochemistry. Of the replication of nucleic acid: such that one complete strand of each double helix is directly derived from its parent. The term was originally proposed (see quot. 1957²) to designate a class of models of the replication of DNA; it is now accepted that its true mechanism of replication falls in this class. ΚΠ 1957 Delbruck & Stent in McElroy & Glass Chem. Basis of Heredity 707 The considerable number of proposed schemes may be divided into three general classes as conservative, semi-conservative, and dispersive. 1957 Delbruck & Stent in McElroy & Glass Chem. Basis of Heredity 709 Semi-conservative mechanisms are those which conserve the atomic identity of single chains of the parental DNA duplex, although effecting a permanent separation of the two chains from each other in the course of replication. 1970 Nature 7 Nov. 522/1 There is good evidence that DNA replication is semi-conservative and involves separation of the two strands which then act as templates. 1976 P. Collard Devel. Microbiol. viii. 106 Semi-conservative replication thus provided a possible answer to the riddle of the stability of the genome from generation to generation. Derivatives ˌsemiconˈservatively adv. ΚΠ 1966 Jrnl. Molecular Biol. 15 372 Since all the DNA is replicated semiconservatively..such a segregation pattern could arise most simply if every chromosome contained all its DNA within a single molecule. 1979 Nature 3 May 75/2 pBR322 DNA replicates semiconservatively and completely in a crude lysate of E. coli. This entry has not yet been fully updated (first published 1986; most recently modified version published online June 2019). < adj.1957
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