bisphosphonaten.

Brit.

/bɪsˈfɒsfəneɪt/, U.S.

/ˌbɪsˈfɑsfəˌneɪt/

Origin: Formed within English, by compounding. Etymons: bis- comb. form¹, phosphonate n.

Etymology: < bis- comb. form¹ + phosphonate n.

An ester containing two phosphonate groups in the molecule; esp. any of a series of such compounds used to treat osteoporosis and other diseases that cause bone fragility.

ΚΠ

1961 Jrnl. Amer. Chem. Soc. 83 1734/2 Tetraethylmethylene bisphosphonate.., prepared from methylene iodide and triethyl phosphite, gave off hydrogen when added to a slurry of sodium hydride at room temperature.

1988 Update 15 Oct. 748/3 The bisphosphonates are potent inhibitors of bone resorption.

2003 Sci. Amer. Mar. 49/2 The most potent bisphosphonates—alendronate (Fosamax) and risedronate (Actonel)..can also increase bone density in most patients by 5 to 10 percent over three years.

2006 Chicago Tribune (Midwest ed.) 1 Oct. x. 30/1 Fosamax..acts, as all the bisphosphonates do, by slowing down the cells that destroy old bone.

This is a new entry (OED Third Edition, September 2018; most recently modified version published online December 2021).

单词	bisphosphonate
释义	bisphosphonaten. Brit. /bɪsˈfɒsfəneɪt/, U.S. /ˌbɪsˈfɑsfəˌneɪt/ Origin: Formed within English, by compounding. Etymons: bis- comb. form¹, phosphonate n. Etymology: < bis- comb. form¹ + phosphonate n. An ester containing two phosphonate groups in the molecule; esp. any of a series of such compounds used to treat osteoporosis and other diseases that cause bone fragility. ΚΠ 1961 Jrnl. Amer. Chem. Soc. 83 1734/2 Tetraethylmethylene bisphosphonate.., prepared from methylene iodide and triethyl phosphite, gave off hydrogen when added to a slurry of sodium hydride at room temperature. 1988 Update 15 Oct. 748/3 The bisphosphonates are potent inhibitors of bone resorption. 2003 Sci. Amer. Mar. 49/2 The most potent bisphosphonates—alendronate (Fosamax) and risedronate (Actonel)..can also increase bone density in most patients by 5 to 10 percent over three years. 2006 Chicago Tribune (Midwest ed.) 1 Oct. x. 30/1 Fosamax..acts, as all the bisphosphonates do, by slowing down the cells that destroy old bone. This is a new entry (OED Third Edition, September 2018; most recently modified version published online December 2021). < n.1961
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