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单词 blocking antibody
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blocking antibody
blocking antibody n. an antibody which, when bound to a specific allergen or antigen, inhibits some physiological or pathological process, by either impeding the function of the molecule to which it is bound or preventing other antibodies from binding to it.
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1938 Jrnl. Allergy 9 429 The authors sought to determine whether sheep, receiving injections of pollen, would manufacture the same type of ‘blocking’ antibody found by Cooke and his co-workers in the sera of human beings receiving pollen therapy for hay fever.
1973 Immunol. Res. (U.S. Dept. Health, Educ., & Welfare) 37/2 This procedure might be used as a ‘holding operation’ until the graft recipient can himself produce blocking antibodies which will protect the transplant from invading lymphocytes.
1981 New Scientist 5 Nov. 372/3 Once a virus has combined with blocking antibody, it is protected from neutralising antibodies—and the result is a small population of virus particles that are resistant to the attack of the immune system.
2012 P. M. Latha Textbk. Immunol. xvii. 185 When the blocking antibodies bind to their own surface antigens, they obstruct binding of other antibodies produced by the immune system against tumor cells.
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