spinulosinn.

/spʌɪnjʊˈləʊsɪn/

Etymology: < modern Latin spīnulōsus, specific epithet of the fungus from which it was first isolated (see spinulose adj.): see -in suffix¹.

Biochemistry.

A purple-black crystalline benzoquinone derivative, C₈H₈O₅, which is produced in cultures of the moulds Penicillium spinulosum and Aspergillus fumigatus.

ΘΚΠ

the world > matter > chemistry > organic chemistry > organic compounds > [noun] > cyclic compounds > named > thiazoles > derivatives

thiazolidine1916

spinulosin1938

1938 Anslow & Raistrick in Biochem. Jrnl. XXXII. 689 Birkinshaw & Raistrick (1931) reported the isolation from cultures of strains in the Penicillium spinulosum Thom series of a new mould metabolic product which was unnamed at that time, but for which the name spinulosin is now proposed.

1946 Nature 17 Aug. 241/1 Fumigatin, spinulosin, helvolic acid, and gliotoxin are the four metabolic products of A. fumigatus which show considerable antibiotic activity.

1950 L. F. Fieser & M. Fieser Org. Chem. (ed. 2) xxxii. 770 Spinulosin..has been prepared from fumigatin by Thiele addition of acetic anhydride, hydrolysis of the resulting tetraacetate, and oxidation.

1979 Biol. Abstr. 67 6332/2 A strain of A. fumigatus (Fresenius)..was grown on a culture medium with added saccharose. The synthesis of..spinulosin was studied under many different temperature, pH and inoculum conditions.

This entry has not yet been fully updated (first published 1986; most recently modified version published online June 2018).

单词	spinulosin
释义	spinulosinn. /spʌɪnjʊˈləʊsɪn/ Etymology: < modern Latin spīnulōsus, specific epithet of the fungus from which it was first isolated (see spinulose adj.): see -in suffix¹. Biochemistry. A purple-black crystalline benzoquinone derivative, C₈H₈O₅, which is produced in cultures of the moulds Penicillium spinulosum and Aspergillus fumigatus. ΘΚΠ the world > matter > chemistry > organic chemistry > organic compounds > [noun] > cyclic compounds > named > thiazoles > derivatives thiazolidine1916 spinulosin1938 1938 Anslow & Raistrick in Biochem. Jrnl. XXXII. 689 Birkinshaw & Raistrick (1931) reported the isolation from cultures of strains in the Penicillium spinulosum Thom series of a new mould metabolic product which was unnamed at that time, but for which the name spinulosin is now proposed. 1946 Nature 17 Aug. 241/1 Fumigatin, spinulosin, helvolic acid, and gliotoxin are the four metabolic products of A. fumigatus which show considerable antibiotic activity. 1950 L. F. Fieser & M. Fieser Org. Chem. (ed. 2) xxxii. 770 Spinulosin..has been prepared from fumigatin by Thiele addition of acetic anhydride, hydrolysis of the resulting tetraacetate, and oxidation. 1979 Biol. Abstr. 67 6332/2 A strain of A. fumigatus (Fresenius)..was grown on a culture medium with added saccharose. The synthesis of..spinulosin was studied under many different temperature, pH and inoculum conditions. This entry has not yet been fully updated (first published 1986; most recently modified version published online June 2018). < n.1938
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