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单词 statin
释义

statinn.1

Brit. /ˈstatɪn/, U.S. /ˈstætn/
Origin: Formed within English, by derivation. Etymons: static adj., -in suffix1.
Etymology: < stat- (perhaps in static adj.; compare stato- comb. form) + -in suffix1.
Biochemistry and Physiology.
A nuclear phosphoprotein that is present in non-replicating and senescent cells, but not in cells that are replicating.
ΘΚΠ
the world > life > biology > substance > proteins > [noun]
casein1838
albuminoid1855
xanthoglobulin1868
myochrome1872
xanthoprotein1883
histone1885
globulose1886
phaseolin1893
leucosin1894
nucleohistone1894
nucleon1895
mucoid1898
protone1898
mucinoid1902
myohaemoglobin1906
nucleoprotamine1911
cytozyme1914
leaf protein1917
cytochrome1925
mucoprotein1925
myoglobin1925
flavoprotein1934
oxymyoglobin1935
ferritin1937
lipovitellin1942
arthropodin1947
trypticase1947
erythropoietin1948
phosvitin1948
opsin1951
orosomucoid1955
metallothionein1960
plastocyanin1961
aequorin1962
ferredoxin1962
LDL1962
fetoprotein1964
thioredoxin1964
actinin1965
adrenodoxin1965
lactoferrin1965
myoglobulin1965
rubredoxin1965
uniporter1967
miraculin1968
nexin1970
bacteriorhodopsin1971
molybdoprotein1971
monellin1972
cytokine1974
ankyrin1975
clathrin1975
electromorph1975
tau1975
uniport1975
microtrabecula1976
porin1976
osteocalcin1977
calmodulin1978
monokine1978
PCNA1978
vimentin1978
interleukin1979
laminin1979
titin1979
villin1979
cyclin1981
triskele1981
acumentin1982
perforin1983
statin1985
activin1986
addressin1988
synuclein1988
chemokine1992
1985 E. Wang in Jrnl. Cell Biol. 101 1695 (title) Rapid disappearance of statin, a nonproliferating and senescent cell-specific protein, upon reentering the process of cell cycling.
1992 Jrnl. Biol. Chem. 267 24067/2 Statin..is expressed in all terminally differentiated tissues, including liver and kidney.
2001 M. E. Warchol in A. F. Jahn & J. Santos-Sacchi Physiol. Ear (ed. 2) xii. 247/2 Statin expression in the cochlea is dramatically reduced after hair cell injury.
This entry has been updated (OED Third Edition, December 2012; most recently modified version published online March 2022).

statinn.2

Brit. /ˈstatɪn/, U.S. /ˈstætn/
Origin: Formed within English, by clipping or shortening. Etymon: lovastatin n.
Etymology: < -statin (in lovastatin n.).
Pharmacology.
Any of a class of drugs that inhibit the action of an enzyme involved in cholesterol synthesis, esp. in the liver, and are used in the management of hypercholesterolaemia (an excess of cholesterol in the bloodstream).Statins are typically cyclic organic compounds such as lactones or pyrroles.
ΚΠ
1987 Circulation 76 532/1 Lovastatin (formerly mevinolin) and synvinolin belong to the new group of statins, which lower serum cholesterol by stimulating removal of LDL via the LDL-receptor pathway.
1993 Independent on Sunday 22 Aug. (Weekend Suppl.) 42/5 The newest class of drugs are the ones called the statins, and there's a really startling increase in the rate at which they're being prescribed.
2010 Daily Tel. 31 Aug. 1/2 A study indicated that one third of patients who were switched from a branded statin to a cheaper generic one received a less powerful equivalent.
This entry has been updated (OED Third Edition, December 2012; most recently modified version published online March 2022).
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