statolonn.

Brit.

/ˈstatəlɒn/, U.S.

/ˈstædəlɑn/

Forms: 1900s– statalon, 1900s– statolon.

Origin: Probably formed within English, by blending. Etymons: -static comb. form, Latin stoloniferum.

Etymology: Probably a blend of -static comb. form and scientific Latin stoloniferum (specific epithet of Penicillium stoloniferum: see quot. 1961 and stoloniferous adj.).

Physiology.

A substance obtained from filtrates of cultures of the mould Penicillium stoloniferum which stimulates the production of interferon in experimental animals and in cultured cells.The active principle of statolon was originally believed to be a complex polysaccharide, but was later identified as double-stranded RNA, probably originating from a mycovirus.

ΚΠ

1961 G. W. Probst & W. J. Kleinschmidt in Federation Proc. (Federation Amer. Soc. Exper. Biol.) 20 441/2 A fermentation broth of Pen. stoloniferium [sic] prophylactically inhibits a number of viruses both in animals and in tissue culture... The active principle, designated as statolon, has been subjected to a variety of purification procedures.

1967 New Scientist 10 Aug. 300/2 W. J. Kleinschmidt and L. F. Ellis have now refined the technique of fractionating statalon, and have discovered, to their surprise, that one of the active fractions contained numerous virus-like hexagonal particles... They have confirmed that..it is these particles that are responsible for stimulating interferon activity in mice.

1978 Nature 29 June 760/1 Tilorone, statolon and Newcastle disease virus (NDV), all potent inducers of interferon in mice, induced a marked increase in spleen cell cytotoxicity.

2006 Immunity 25 344/1 Double-stranded RNA from statolon or helenine, and also synthetic double-stranded RNA,..readily triggered IFN [= interferon] production in intact animals or in cell cultures.

This entry has been updated (OED Third Edition, December 2012; most recently modified version published online March 2022).

单词	statolon
释义	statolonn. Brit. /ˈstatəlɒn/, U.S. /ˈstædəlɑn/ Forms: 1900s– statalon, 1900s– statolon. Origin: Probably formed within English, by blending. Etymons: -static comb. form, Latin stoloniferum. Etymology: Probably a blend of -static comb. form and scientific Latin stoloniferum (specific epithet of Penicillium stoloniferum: see quot. 1961 and stoloniferous adj.). Physiology. A substance obtained from filtrates of cultures of the mould Penicillium stoloniferum which stimulates the production of interferon in experimental animals and in cultured cells.The active principle of statolon was originally believed to be a complex polysaccharide, but was later identified as double-stranded RNA, probably originating from a mycovirus. ΚΠ 1961 G. W. Probst & W. J. Kleinschmidt in Federation Proc. (Federation Amer. Soc. Exper. Biol.) 20 441/2 A fermentation broth of Pen. stoloniferium [sic] prophylactically inhibits a number of viruses both in animals and in tissue culture... The active principle, designated as statolon, has been subjected to a variety of purification procedures. 1967 New Scientist 10 Aug. 300/2 W. J. Kleinschmidt and L. F. Ellis have now refined the technique of fractionating statalon, and have discovered, to their surprise, that one of the active fractions contained numerous virus-like hexagonal particles... They have confirmed that..it is these particles that are responsible for stimulating interferon activity in mice. 1978 Nature 29 June 760/1 Tilorone, statolon and Newcastle disease virus (NDV), all potent inducers of interferon in mice, induced a marked increase in spleen cell cytotoxicity. 2006 Immunity 25 344/1 Double-stranded RNA from statolon or helenine, and also synthetic double-stranded RNA,..readily triggered IFN [= interferon] production in intact animals or in cell cultures. This entry has been updated (OED Third Edition, December 2012; most recently modified version published online March 2022). < n.1961
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