stilbamidinen.

/stɪlˈbamɪdiːn/

Etymology: < stilb- (in stilbene n.) + amidine ( < amid- (in amide n.) + -ine suffix⁵).

Pharmacology.

A diamidine derivative, (H₂N)(HN)C·C₆H₄·CH:CH·C₆H₄·C(NH)(NH₂), of stilbene which has antiprotozoal properties and has been used, usually in the form of its isethionate, in the treatment of trypanosomiasis and leishmaniasis.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medicines for specific purpose > remedies for parasitic infections > [noun] > other internal parasiticides > specific drugs

phenanthridine1890

trypan red1905

trypan blue1911

tryparsamide1921

Bayer 2051922

stibophen1941

stilbamidine1941

suramin1941

mepacrine1943

PABA1943

metronidazole1960

stibocaptate1962

1941 J. D. Fulton & W. Yorke in Ann. Trop. Med. & Parasitol. 35 229 The name ‘stilbamidine’ has been given to 4:4′-diamidino stilbene, ‘propamidine’ to 4:4′-diamidino diphenoxy propane, ‘pentamidine’ to 4:4′-diamidino diphenoxy pentane, and ‘phenamidine’ to 4:4′-diamidino diphenyl ether.

1958 J. H. Burn Lect. Notes Pharmacol. (ed. 5) 110 Stilbamidine is no longer used [in the treatment of leishmaniasis] because it is toxic to the 5th nerve.

1977 Jrnl. Pharmacol. & Exper. Therapeutics 201 555/1 Pentamidine, stilbamidine and their close analogs are known to interfere with nucleic acid and protein synthesis.

This entry has not yet been fully updated (first published 1986; most recently modified version published online June 2018).

单词	stilbamidine
释义	stilbamidinen. /stɪlˈbamɪdiːn/ Etymology: < stilb- (in stilbene n.) + amidine ( < amid- (in amide n.) + -ine suffix⁵). Pharmacology. A diamidine derivative, (H₂N)(HN)C·C₆H₄·CH:CH·C₆H₄·C(NH)(NH₂), of stilbene which has antiprotozoal properties and has been used, usually in the form of its isethionate, in the treatment of trypanosomiasis and leishmaniasis. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > remedies for parasitic infections > [noun] > other internal parasiticides > specific drugs phenanthridine1890 trypan red1905 trypan blue1911 tryparsamide1921 Bayer 2051922 stibophen1941 stilbamidine1941 suramin1941 mepacrine1943 PABA1943 metronidazole1960 stibocaptate1962 1941 J. D. Fulton & W. Yorke in Ann. Trop. Med. & Parasitol. 35 229 The name ‘stilbamidine’ has been given to 4:4′-diamidino stilbene, ‘propamidine’ to 4:4′-diamidino diphenoxy propane, ‘pentamidine’ to 4:4′-diamidino diphenoxy pentane, and ‘phenamidine’ to 4:4′-diamidino diphenyl ether. 1958 J. H. Burn Lect. Notes Pharmacol. (ed. 5) 110 Stilbamidine is no longer used [in the treatment of leishmaniasis] because it is toxic to the 5th nerve. 1977 Jrnl. Pharmacol. & Exper. Therapeutics 201 555/1 Pentamidine, stilbamidine and their close analogs are known to interfere with nucleic acid and protein synthesis. This entry has not yet been fully updated (first published 1986; most recently modified version published online June 2018). < n.1941
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