subclonen.

Brit.

/ˈsʌbkləʊn/, U.S.

/ˈsəbˌkloʊn/

Origin: Formed within English, by derivation. Etymons: sub- prefix, clone n.

Etymology: < sub- prefix + clone n.

Biology.

A clonal population derived from an existing clone; esp. (Genetics) a plasmid or other vector containing a fragment of DNA which has been transferred (wholly or in part) from a different vector.

ΚΠ

1915 A. B. Stout Establishment Varieties Coleus 13 All the plants derived from plant No. 1 constitute a main clone, itself made up of numerous subclones.

1961 Virology 13 160/2 Subclones showing the morphology characteristic of the superinfecting virus were plated for virus release.

1984 Proc. National Acad. Sci. U.S.A. 81 4117/2 The subclones contain genomic and cDNA sequences.

1996 R. Dawkins Climbing Mount Improbable (1997) iii. 75 A new bad mutation will quickly disappear, dragging its subclone of freaks down with it.

2005 Plant Cell 17 1642/2 Each subclone was amplified by PCR using universal primers annealing to the flanking vector sequences.

This entry has been updated (OED Third Edition, June 2012; most recently modified version published online March 2022).

subclonev.

Brit.

/ˈsʌbkləʊn/, U.S.

/ˈsəbˌkloʊn/

Origin: Formed within English, by derivation. Etymons: sub- prefix, clone v.

Etymology: < sub- prefix + clone v. Compare earlier subclone n., and slightly earlier subcloning n.

Genetics.

transitive. To create a new clone from (an existing clonal population); esp. (in later use) to clone (a cloned fragment of DNA, or part of such a fragment) in a different vector, plasmid, etc.

ΚΠ

1961 Virology 13 160/2 Clones showing the morphology characteristic of the original virus were subcloned.

1989 B. Alberts et al. Molecular Biol. Cell (ed. 2) xxi. 1201 (caption) Cells derived from a single cancer cell line are subcloned, and standard aliquots of each subclone are tested.

1993 Ann. Human Genetics 57 12 Some of these segments were subcloned in pUC vectors and their nucleotide sequence was determined.

2007 New Scientist 17 Feb. 83 (advt.) Your responsibilities will be to isolate and analyse antibody genes from hybridomas and subsequently sub-clone them into a variety of formats for eukaryotic expression.

This entry has been updated (OED Third Edition, June 2012; most recently modified version published online March 2022).

单词	subclone
释义	subclonen. Brit. /ˈsʌbkləʊn/, U.S. /ˈsəbˌkloʊn/ Origin: Formed within English, by derivation. Etymons: sub- prefix, clone n. Etymology: < sub- prefix + clone n. Biology. A clonal population derived from an existing clone; esp. (Genetics) a plasmid or other vector containing a fragment of DNA which has been transferred (wholly or in part) from a different vector. ΚΠ 1915 A. B. Stout Establishment Varieties Coleus 13 All the plants derived from plant No. 1 constitute a main clone, itself made up of numerous subclones. 1961 Virology 13 160/2 Subclones showing the morphology characteristic of the superinfecting virus were plated for virus release. 1984 Proc. National Acad. Sci. U.S.A. 81 4117/2 The subclones contain genomic and cDNA sequences. 1996 R. Dawkins Climbing Mount Improbable (1997) iii. 75 A new bad mutation will quickly disappear, dragging its subclone of freaks down with it. 2005 Plant Cell 17 1642/2 Each subclone was amplified by PCR using universal primers annealing to the flanking vector sequences. This entry has been updated (OED Third Edition, June 2012; most recently modified version published online March 2022). subclonev. Brit. /ˈsʌbkləʊn/, U.S. /ˈsəbˌkloʊn/ Origin: Formed within English, by derivation. Etymons: sub- prefix, clone v. Etymology: < sub- prefix + clone v. Compare earlier subclone n., and slightly earlier subcloning n. Genetics. transitive. To create a new clone from (an existing clonal population); esp. (in later use) to clone (a cloned fragment of DNA, or part of such a fragment) in a different vector, plasmid, etc. ΚΠ 1961 Virology 13 160/2 Clones showing the morphology characteristic of the original virus were subcloned. 1989 B. Alberts et al. Molecular Biol. Cell (ed. 2) xxi. 1201 (caption) Cells derived from a single cancer cell line are subcloned, and standard aliquots of each subclone are tested. 1993 Ann. Human Genetics 57 12 Some of these segments were subcloned in pUC vectors and their nucleotide sequence was determined. 2007 New Scientist 17 Feb. 83 (advt.) Your responsibilities will be to isolate and analyse antibody genes from hybridomas and subsequently sub-clone them into a variety of formats for eukaryotic expression. This entry has been updated (OED Third Edition, June 2012; most recently modified version published online March 2022). < n.1915v.1961
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