synucleinn.

Brit.

/sɪˈnjuːklɪɪn/, U.S.

/səˈn(j)ukliən/

Origin: Formed within English, by derivation. Etymons: synaptic adj., nucleus n., -in suffix¹.

Etymology: < sy- (in synaptic adj.) + nucle- (in nucleus n.) + -in suffix¹; the proteins were isolated in a study of the synapses and electromotor nucleus of the electric organ in the electric ray Torpedo (compare quot. 1988).

Biochemistry.

Any of a group of three small proteins which are found in neurons, esp. near synapses, and are of uncertain function; esp. (in full alpha-synuclein) a protein of this family which is the major component of an abnormal structure (the Lewy body) found in neurons in Parkinson's disease and certain other neurodegenerative disorders.Mutations in the gene coding for alpha-synuclein are responsible for inherited forms of Parkinson's disease.

ΘΚΠ

the world > life > biology > substance > proteins > [noun]

casein1838

albuminoid1855

xanthoglobulin1868

myochrome1872

xanthoprotein1883

histone1885

globulose1886

phaseolin1893

leucosin1894

nucleohistone1894

nucleon1895

mucoid1898

protone1898

mucinoid1902

myohaemoglobin1906

nucleoprotamine1911

cytozyme1914

leaf protein1917

cytochrome1925

mucoprotein1925

myoglobin1925

flavoprotein1934

oxymyoglobin1935

ferritin1937

lipovitellin1942

arthropodin1947

trypticase1947

erythropoietin1948

phosvitin1948

opsin1951

orosomucoid1955

metallothionein1960

plastocyanin1961

aequorin1962

ferredoxin1962

LDL1962

fetoprotein1964

thioredoxin1964

actinin1965

adrenodoxin1965

lactoferrin1965

myoglobulin1965

rubredoxin1965

uniporter1967

miraculin1968

nexin1970

bacteriorhodopsin1971

molybdoprotein1971

monellin1972

cytokine1974

ankyrin1975

clathrin1975

electromorph1975

tau1975

uniport1975

microtrabecula1976

porin1976

osteocalcin1977

calmodulin1978

monokine1978

PCNA1978

vimentin1978

interleukin1979

laminin1979

titin1979

villin1979

cyclin1981

triskele1981

acumentin1982

perforin1983

statin1985

activin1986

addressin1988

synuclein1988

chemokine1992

1988 L. Maroteaux et al. in Jrnl. Neuroscience 8 2804/1 We used an antiserum against purified cholinergic synaptic vesicles from Torpedo and expression screening to isolate a cDNA clone encoding synuclein, a 143 amino acid neuron-specific protein.

1994 R. Jakes et al. in FEBS Lett. 345 27 We refer to the 140 and 134 amino acid proteins as alpha-synuclein and beta-synuclein, respectively.

2006 M. Goedert & M. G. Spillantini in G. Siegel et al. Basic Neurochem. (ed. 7) xlv. 746/2 Synucleins are abundant, nervous-system-enriched proteins whose physiological functions are only incompletely understood.

2008 New Scientist 12 Apr. 11/2 The diseased cells contain structures called Lewy bodies, accumulations of a protein called alpha-synuclein that are a hallmark of Parkinson's.

This is a new entry (OED Third Edition, September 2012; most recently modified version published online March 2022).

单词	synuclein
释义	synucleinn. Brit. /sɪˈnjuːklɪɪn/, U.S. /səˈn(j)ukliən/ Origin: Formed within English, by derivation. Etymons: synaptic adj., nucleus n., -in suffix¹. Etymology: < sy- (in synaptic adj.) + nucle- (in nucleus n.) + -in suffix¹; the proteins were isolated in a study of the synapses and electromotor nucleus of the electric organ in the electric ray Torpedo (compare quot. 1988). Biochemistry. Any of a group of three small proteins which are found in neurons, esp. near synapses, and are of uncertain function; esp. (in full alpha-synuclein) a protein of this family which is the major component of an abnormal structure (the Lewy body) found in neurons in Parkinson's disease and certain other neurodegenerative disorders.Mutations in the gene coding for alpha-synuclein are responsible for inherited forms of Parkinson's disease. ΘΚΠ the world > life > biology > substance > proteins > [noun] casein1838 albuminoid1855 xanthoglobulin1868 myochrome1872 xanthoprotein1883 histone1885 globulose1886 phaseolin1893 leucosin1894 nucleohistone1894 nucleon1895 mucoid1898 protone1898 mucinoid1902 myohaemoglobin1906 nucleoprotamine1911 cytozyme1914 leaf protein1917 cytochrome1925 mucoprotein1925 myoglobin1925 flavoprotein1934 oxymyoglobin1935 ferritin1937 lipovitellin1942 arthropodin1947 trypticase1947 erythropoietin1948 phosvitin1948 opsin1951 orosomucoid1955 metallothionein1960 plastocyanin1961 aequorin1962 ferredoxin1962 LDL1962 fetoprotein1964 thioredoxin1964 actinin1965 adrenodoxin1965 lactoferrin1965 myoglobulin1965 rubredoxin1965 uniporter1967 miraculin1968 nexin1970 bacteriorhodopsin1971 molybdoprotein1971 monellin1972 cytokine1974 ankyrin1975 clathrin1975 electromorph1975 tau1975 uniport1975 microtrabecula1976 porin1976 osteocalcin1977 calmodulin1978 monokine1978 PCNA1978 vimentin1978 interleukin1979 laminin1979 titin1979 villin1979 cyclin1981 triskele1981 acumentin1982 perforin1983 statin1985 activin1986 addressin1988 synuclein1988 chemokine1992 1988 L. Maroteaux et al. in Jrnl. Neuroscience 8 2804/1 We used an antiserum against purified cholinergic synaptic vesicles from Torpedo and expression screening to isolate a cDNA clone encoding synuclein, a 143 amino acid neuron-specific protein. 1994 R. Jakes et al. in FEBS Lett. 345 27 We refer to the 140 and 134 amino acid proteins as alpha-synuclein and beta-synuclein, respectively. 2006 M. Goedert & M. G. Spillantini in G. Siegel et al. Basic Neurochem. (ed. 7) xlv. 746/2 Synucleins are abundant, nervous-system-enriched proteins whose physiological functions are only incompletely understood. 2008 New Scientist 12 Apr. 11/2 The diseased cells contain structures called Lewy bodies, accumulations of a protein called alpha-synuclein that are a hallmark of Parkinson's. This is a new entry (OED Third Edition, September 2012; most recently modified version published online March 2022). < n.1988
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