Tay-Sachsn.

/teɪˈsaks/

Etymology: < the names of Warren Tay (1843–1927), British ophthalmologist, and Bernard Sachs (1858–1944), American physician and neurologist. Named in German by H. Higier 1901, in Neurologisches Centralblatt XX. 851.

Pathology.

Used attributively and absol. with reference to a fatal inherited metabolic disorder in which an enzyme deficiency causes accumulation of a ganglioside in the brain and elsewhere, resulting in idiocy and death in childhood (described by Tay and Sachs in 1881 and 1887 respectively).

ΘΚΠ

the world > health and disease > ill health > a disease > disorders of internal organs > metabolic disorders > [noun] > other metabolic disorders

xanthomatosis1900

Tay-Sachs1907

ketosis1917

protein shock1917

hyperinsulinism1924

Niemann–Pick1928

tyrosinosis1932

von Gierke's disease1933

phenylketonuria1935

cystic fibrosis1938

mucoviscidosis1945

cystinosis1949

oxalosis1952

McArdle1957

orotic aciduria1959

PKU1961

sphingolipidosis1962

Reye's syndrome1965

Menkes1969

1907 Index Medicus V. 841/1 Hereditary infantile cerebellar ataxy and the Tay-Sachs disease.

1937 I. H. Page Chem. of Brain iii. 93 (heading) Tay-Sachs amaurotic familial idiocy.

1974 Sci. Amer. Mar. 63/2 (advt.) A Tay-Sachs child develops normally for his first six months. Then, as excessive fatty deposits accumulate in his brain cells, he regresses... Usually before his fifth birthday, he dies.

1975 Nature 8 May 101/3 Israel's best known ethnic malady is Tay-Sachs Disease, a fatal genetic disorder limited almost entirely to infants whose forebears came here from certain parts of East Europe.

This entry has not yet been fully updated (first published 1986; most recently modified version published online September 2018).

单词	tay-sachs
释义	Tay-Sachsn. /teɪˈsaks/ Etymology: < the names of Warren Tay (1843–1927), British ophthalmologist, and Bernard Sachs (1858–1944), American physician and neurologist. Named in German by H. Higier 1901, in Neurologisches Centralblatt XX. 851. Pathology. Used attributively and absol. with reference to a fatal inherited metabolic disorder in which an enzyme deficiency causes accumulation of a ganglioside in the brain and elsewhere, resulting in idiocy and death in childhood (described by Tay and Sachs in 1881 and 1887 respectively). ΘΚΠ the world > health and disease > ill health > a disease > disorders of internal organs > metabolic disorders > [noun] > other metabolic disorders xanthomatosis1900 Tay-Sachs1907 ketosis1917 protein shock1917 hyperinsulinism1924 Niemann–Pick1928 tyrosinosis1932 von Gierke's disease1933 phenylketonuria1935 cystic fibrosis1938 mucoviscidosis1945 cystinosis1949 oxalosis1952 McArdle1957 orotic aciduria1959 PKU1961 sphingolipidosis1962 Reye's syndrome1965 Menkes1969 1907 Index Medicus V. 841/1 Hereditary infantile cerebellar ataxy and the Tay-Sachs disease. 1937 I. H. Page Chem. of Brain iii. 93 (heading) Tay-Sachs amaurotic familial idiocy. 1974 Sci. Amer. Mar. 63/2 (advt.) A Tay-Sachs child develops normally for his first six months. Then, as excessive fatty deposits accumulate in his brain cells, he regresses... Usually before his fifth birthday, he dies. 1975 Nature 8 May 101/3 Israel's best known ethnic malady is Tay-Sachs Disease, a fatal genetic disorder limited almost entirely to infants whose forebears came here from certain parts of East Europe. This entry has not yet been fully updated (first published 1986; most recently modified version published online September 2018). < n.1907
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