telomerasen.

Brit.

/tɛˈlɒməreɪz/, U.S.

/tɛˈlɑməˌreɪz/,

/tɛˈlɑməˌreɪs/

Origin: Formed within English, by derivation. Etymons: telomere n. at telo- comb. form¹ , -ase suffix.

Etymology: < telomere n. at telo- comb. form¹ + -ase suffix, after polymerase n. (replacing the fuller phrase telomere terminal transferase (1985)).

Genetics.

A ribonucleoprotein enzyme, incorporating a reverse transcriptase and an RNA template, which can extend the telomere region at the end of a chromosome by adding a characteristic repeated DNA sequence to the ends of the strands, so enabling continued chromosome replication.

ΚΠ

1987 C. W. Greider & E. H. Blackburn in Cell 51 887 Telomerase was shown to be a ribonucleoprotein complex whose RNA and protein components were both essential for activity.

1995 Sci. News 25 Nov. 362/1 Telomeres, which cap the ends of chromosomes, and telomerase, the odd enzyme that constructs those caps, may hold the key to understanding what determines the life span of human cells.

2004 Jrnl. Cell Biol. 164 637/1 Telomerase is mechanistically a reverse transcriptase, but to the grateful genomes on which it operates it is a chromosome end-specific DNA polymerase.

This is a new entry (OED Third Edition, December 2006; most recently modified version published online March 2022).

单词	telomerase
释义	telomerasen. Brit. /tɛˈlɒməreɪz/, U.S. /tɛˈlɑməˌreɪz/, /tɛˈlɑməˌreɪs/ Origin: Formed within English, by derivation. Etymons: telomere n. at telo- comb. form¹ , -ase suffix. Etymology: < telomere n. at telo- comb. form¹ + -ase suffix, after polymerase n. (replacing the fuller phrase telomere terminal transferase (1985)). Genetics. A ribonucleoprotein enzyme, incorporating a reverse transcriptase and an RNA template, which can extend the telomere region at the end of a chromosome by adding a characteristic repeated DNA sequence to the ends of the strands, so enabling continued chromosome replication. ΚΠ 1987 C. W. Greider & E. H. Blackburn in Cell 51 887 Telomerase was shown to be a ribonucleoprotein complex whose RNA and protein components were both essential for activity. 1995 Sci. News 25 Nov. 362/1 Telomeres, which cap the ends of chromosomes, and telomerase, the odd enzyme that constructs those caps, may hold the key to understanding what determines the life span of human cells. 2004 Jrnl. Cell Biol. 164 637/1 Telomerase is mechanistically a reverse transcriptase, but to the grateful genomes on which it operates it is a chromosome end-specific DNA polymerase. This is a new entry (OED Third Edition, December 2006; most recently modified version published online March 2022). < n.1987
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