单词 | thioguanine |
释义 | > as lemmasthioguanine thioguanine n. Brit. /ˌθʌɪə(ʊ)ˈɡwɑːniːn/ , U.S. /ˌθaɪoʊˈɡwɑˌnin/ a thio analogue of guanine with cytotoxic properties, given orally in the treatment of leukaemia.ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for cancer or leukemia amethopterin1948 Myleran1952 Laetrile1953 thioguanine1953 thioTEPA1953 mercaptopurine1954 methotrexate1955 busulfan1956 chlorambucil1956 cyclophosphamide1960 vinblastine1962 vincristine1962 levamisole1969 vinca alkaloid1970 doxorubicin1971 tamoxifen1972 Airol1974 trastuzumab1997 thiotepa- 1953 Jrnl. Biol. Chem. 204 38 The preparation of thioguanine completely free from guanine has proved difficult. 1962 Jrnl. Amer. Med. Assoc. 10 Mar. 791/1 The drug used in this study, 6-thioguanine, is an adenine analogue closely related to 6-mercaptopurine. 1977 Cancer 40 998/1 The introduction of cytosine arabinoside..and 6-thioguanine..significantly improved the therapy of AML [sc. acute myeloblastic leukaemia] in adults. 1988 New Scientist 22 Oct. 27/2 These drugs, 6-mercaptopurine and thioguanine, are still used in the treatment of leukaemia. < as lemmas |
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