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toxic epidermal necrolysis
necrolysis n. 
/nɛˈkrɒlᵻsɪs/, /nɛˈkrɑləsəs/ necrosis and loosening or dissolution of cells or tissue; (Medicine) (in full toxic epidermal necrolysis) a syndrome characterized by extensive necrosis of the epidermis with blister formation and peeling that resembles scalding, typically occurring as an adverse reaction to a drug.
Brit. /nᵻˈkrɒlᵻsɪs/
, /nᵻˈkrɒlᵻsɪs//nɛˈkrɒlᵻsɪs/U.S. /nəˈkrɑləsəs/
, /nəˈkrɑləsəs//nɛˈkrɑləsəs/ΚΠ
1956 A. Lyell in Brit. Jrnl. Dermatol. 68 361 Such a very definite syndrome as this should have a name to distinguish it from other toxic erythema and bullous eruptions, and I suggest that it might be called ‘Toxic epidermal necrolysis’. The word necrolysis avoids the ambiguity of epidermolysis and the picture of ulceration and gangrene which is conjured up by necrosis.
1985 Paleobiology 11 105 The past decade has seen a change in emphasis..to more experimental, process-oriented investigations of necrolysis, stratification, and diagnosis of organic remains in modern environments.
1993 Fort Collins Triangle Rev. (Colorado) 4 a/1 Mrs Smith..was diagnosed as having Toxic Epidermal Necrolysis..a rare skin disease in which the skin sloughs off as in a third degree burn.
1995 Jrnl. Vet. Internal Med. 9 399/1 In dogs, hepatocutaneous syndrome..is characterized by parakeratosis, superficial necrolysis, and basilar hyperplasia of the epidermis.
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