transpeptidationn.
/ˌtrɑːnspɛptɪˈdeɪʃən//ˌtranspɛptɪˈdeɪʃən/ Biochemistry.
Any reaction in which a peptide bond is broken and the free carboxyl (or amino) group joined to the amino (or carboxyl) group of another molecule so as to form a new peptide bond.
ΚΠ
1950 J. S. Fruton in Yale Jrnl. Biol. & Med. XXII. 264 Reactions of this type may be termed ‘transpeptidation’ or ‘transamidation’ processes.
1975 Nature 10 Apr. 482/2 Various cell-free transpeptidation systems are now known to be sensitive to penicillin.
Derivatives
transˈpeptidase n. [-ase suffix] any enzyme that catalyses transpeptidation.
ΚΠ
1952 C. S. Hanes et al. in Biochem. Jrnl. LI. 25/1 The enzyme will be referred to as γ-glutamyl transpeptidase.
1981 Sci. Amer. June 68/1 The vulnerable enzymes are either transpeptidases (which cross-link one peptide chain of new peptidoglycan to another by displacing a terminal d-alanine) or d-carboxypeptidases (which remove a terminal d-alanine by hydrolysis without cross-linking taking place).
This entry has not yet been fully updated (first published 1986; most recently modified version published online September 2018).
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n.1950