valinomycinn.
/ˌvalɪnəʊˈmʌɪsɪn/ Pharmacology.
A dodecapeptide obtained from the fungus Streptomyces fulvissimus, which has antibiotic activity against Gram-positive bacteria and is used experimentally.
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the world > health and disease > healing > medicines or physic > medicines for specific purpose > antibiotics > [noun] > other antibiotics
pyocyanase1900
fumigatin1938
M and B1938
gramicidin1940
tyrocidine1940
tyrothricin1940
clavacin1942
fumigacin1942
streptothricin1942
aspergillic acid1943
aspergillin1943
clavatin1943
helvolic acid1943
streptomycin1944
subtilin1944
bacitracin1945
viridin1945
javanicin1946
nisin1947
nitrofurazone1947
polymyxin1947
aureomycin1948
chloramphenicol1949
clitocybin1949
neomycin1949
Terramycin1950
viomycin1950
cephalosporin1951
fumagillin1951
nigericin1951
achromycin1952
carbomycin1952
erythromycin1952
nystatin1952
oxytetracycline1952
tetracycline1952
chlortetracycline1953
nitrofurantoin1953
oligomycin1953
puromycin1953
bacteriocin1954
albomycin1955
spiramycin1955
valinomycin1955
amphotericin B1956
mitomycin1956
novobiocin1956
oleandomycin1956
paromomycin1956
vancomycin1956
kanamycin1957
macrolide1957
ristocetin1957
streptovaricin1957
ethionamide1959
rifamycin1959
strep1959
mithramycin1960
fucidin1961
virginiamycin1961
cephalothin1962
fusidic acid1962
nonactin1962
trimethoprim1962
daunomycin1963
lincomycin1963
anthracycline1964
cephaloridine1964
spectinomycin1964
doxycycline1966
rifampicin1966
minocycline1967
rifampin1968
Adriamycin1969
daunorubicin1969
ribostamycin1970
doxorubicin1971
tobramycin1971
milbemycin1975
fluoroquinolone1984
1955 Chem. Abstr. 49 16068 Streptomyces fulvissimus grown in a medium..gave 2·3g. of dry mycelium (I) per l. It..gave an oil, which on cooling deposited valinomycin.
1969 New Scientist 31 July 225/1 Valinomycin is lethal to cells because it makes the membranes of mitochondria permeable to ions, particularly potassium, and stops them making energy available to all the other processes in the cell.
1979 Sci. Amer. Sept. 77/3 To prove that the gradient existed between the mitochondria and the surrounding cytoplasm the investigators added the drug valinomycin, which increases the rate of cell respiration and establishes an equilibrium in the concentration of potassium ions on both sides of the mitochondrial membrane.
This entry has not yet been fully updated (first published 1986; most recently modified version published online June 2021).
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n.1955