valproicadj.
/valˈprəʊɪk/ Pharmacology.
2-Propylpentanoic acid, C8H15OOH, a branched-chain fatty acid; also, a salt of this.
ΘΚΠ
the world > health and disease > healing > medicines or physic > medicines for specific purpose > sedatives, antispasmodics, etc. > [noun] > antispasmodic or anticonvulsant > specific substances or preparations
Dilantin1938
phenytoin1942
Artane1948
Mysoline1949
mephenesin1952
troxidone1952
primidone1953
acetazolamide1954
orphenadrine1957
tetrabenazine1958
ethosuximide1960
methsuximide1965
clonazepam1970
valproic1972
valproate1974
1972 Approved Names (Brit. Pharmacopœia Comm.) Suppl. iv. 6 Valproic acid.
1977 Lancet 22 Oct. 860/1 The antiepileptic activity of valproic acid (dipropylacetic acid) was recognized serendipitously when the agent was administered to animals as a vehicle for a series of test compounds.
Derivatives
valˈproate n. a salt of this acid, esp. the sodium salt, an anticonvulsant drug given orally in cases of epilepsy.
ΘΚΠ
the world > health and disease > healing > medicines or physic > medicines for specific purpose > sedatives, antispasmodics, etc. > [noun] > antispasmodic or anticonvulsant > specific substances or preparations
Dilantin1938
phenytoin1942
Artane1948
Mysoline1949
mephenesin1952
troxidone1952
primidone1953
acetazolamide1954
orphenadrine1957
tetrabenazine1958
ethosuximide1960
methsuximide1965
clonazepam1970
valproic1972
valproate1974
1974 Brit. Med. Jrnl. 15 June 584/1 The anticonvulsant effects of sodium dipropylacetate (sodium valproate) were first reported in France.
1983 F. E. Dreifuss in Pedley & Meldrum Rec. Adv. in Epilepsy I. iii. 35 Clinical experience with Valproate extends over nearly 20 years.
1983 F. E. Dreifuss in Pedley & Meldrum Rec. Adv. in Epilepsy I. iii. 35 The term Valproate is used here to refer both to valproic acid and its salts (sodium or magnesium).
This entry has not yet been fully updated (first published 1986; most recently modified version published online September 2018).
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adj.1972