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Waldenström's macroglobulinaemia
An increased level of macroglobulins, esp. of immunoglobulin M, in the blood; spec. (more fully Waldenström's macroglobulinaemia 
/ˌvɑldənstrəmz ˌmækroʊˌɡlɑbjələˈnimiə/) a lymphoproliferative disorder affecting chiefly the bone marrow and the reticuloendothelial system, characterized by the presence of monoclonal immunoglobulin M (or, rarely, IgG or IgA).
Brit. /ˌvaldənstrəːmz makrə(ʊ)ɡlɒbjᵿlᵻˈniːmɪə/
, /ˌvaldənstrəːmz makrə(ʊ)ɡlɒbjᵿlᵻˈniːmɪə/U.S. /ˌwɑldənstrəmz ˌmækroʊˌɡlɑbjələˈnimiə/
, /ˌwɑldənstrəmz ˌmækroʊˌɡlɑbjələˈnimiə//ˌvɑldənstrəmz ˌmækroʊˌɡlɑbjələˈnimiə/ΘΚΠ
the world > health and disease > ill health > a disease > disorders of internal organs > disorders of blood > [noun] > excess of other substances
hyperinosis1845
uricaemia1866
acetonaemia1874
hyperalbuminosis1876
chloraemia1890
acidaemia1891
hypercholesteraemia1894
hyperglycaemia1894
hyperlipaemia1894
hyperuricaemia1894
lymphocytosis1896
urataemia1897
acidosis1900
basophilia1905
mononucleosis1907
hypercapnia1908
thrombocytosis1909
thyrotoxicosis1911
monocytosis1914
hypercholesterolaemia1916
hyperparathyroidism1917
ketonaemia1917
lymphocytoma1920
hyperchloraemia1921
alkalaemia1922
hyperproteinaemia1922
reticulosis1922
hyperbilirubinaemia1923
hyperinsulinaemia1924
hypercalcaemia1925
hyperphosphataemia1926
reticulocytosis1926
hypernatraemia1932
hyperpotassaemia1932
thrombocythaemia1932
hypermagnesaemia1933
hyperglobulinaemia1936
granulocytosis1937
myeloblastosis1937
hypergammaglobulinaemia1947
hyperkalaemia1949
macroglobulinaemia1949
aldosteronism1954
Waldenström1961
mono1964
tyrosinaemia1965
methylmalonic acidaemia1969
1949 K. Pedersen in Jrnl. Franklin Inst. 248 570 In a few rare cases of essential macroglobulinemia.., a very high concentration of the 20 S component has been found.
1961 Lancet 5 Aug. 289/2 While there can be no doubt that Waldenström's syndrome exists, it seems that such increases in macroglobulins are not confined to a single disease entity. The term macroglobulinæmia will therefore be used in this paper to refer to the presence in the serum of increased amounts of macroglobulins, regardless of the clinical associations.
1968 New Eng. Jrnl. Med. 18 Apr. 918/1 The very latest material concerning..macroglobulinemia after fetal infection..evidently did not make publishing deadlines.
1971 D. Hawkins in S. O. Freedman Clin. Immunol. vi. 179 Patients with Waldenstrom's macroglobulinemia may have proteinuria and even nephrotic syndrome.
1992 Saudi Med. Jrnl. 12 467/1 Other related conditions in which an M-protein can be produced are Waldenstrom's macroglobulinaemia..and α-heavy chain disease.
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