the world > action or operation > harm or detriment > disadvantage > uselessness > uselessness, vanity, or futility > [adverb] > uselessly or unprofitably
a1382 (Douce 369(1)) (1850) Isa. xxx. 7 Egipt forsothe wastli, and in veyn [L. frustra et vane, a1425 in veyn, and idili] shal helpen.