butyrophenonen.
/ˌbjuːtɪrəʊˈfɛnəʊn/ Chemistry and Pharmacology.
n-Propyl phenyl ketone, C6H5·CO·(CH2)2CH3, a liquid. Also, any compound whose structure contains this group.
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the world > matter > chemistry > organic chemistry > ketones > [noun] > others
pyroacetic ether1810
pyroacetic spirit1810
pyroacetic acid1819
margarone1834
oleone1834
stearone1836
acetone1838
valerone1839
benzoin1863
acetophenone1871
anthrone1881
ionone1893
Michler's ketone1897
chalcone1899
butanone1902
butyrophenone1908
alkenone1945
tropolone1945
1908 Chem. Abstr. 2 1426 With C6H6 and AlCl3 it forms the butyrophenone, C8H4O2: NCH2CH2CH2Bz; flat, pointed needles, 132-3°.
1917 Chem. Abstr. 11 3753/2 Butyrophenone, CH3CH2CH2COPh.
1961 Jrnl. Pharmaceutical Sci. 50 350/1 On synthesizing a series of over 1,000 new substituted piperidines, it was found that the basic butyrophenones therein had powerful C.N.S.-depressant activity in various species.
1967 I. L. Finar Org. Chem. (ed. 5) I. xxvii. 707 Willgerodt reaction...The amido-group is always formed at the end of the chain whatever the size of the R group in C6H5·CO·R; e.g., butyrophenone forms γ-phenylbutyramide... C6H5·CH2·CH2·CH2·CONH·2.
1968 Brit. Med. Jrnl. 27 Apr. 230/2 The butyrophenone derivatives are non-phenothiazine drugs which are useful in the treatment of psychotic patients, particularly those with manic overactivity.
1984 Brit. National Formulary (Brit. Med. Assoc.) 8 139/2 Drugs of other chemical groups tend to resemble the phenothiazines... They include the butyrophenones (benperidol, droperidol, haloperidol, and trifluperidol); [etc.].
This entry has not yet been fully updated (first published 1993; most recently modified version published online September 2018).
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n.1908