To the very heart or root of a matter; so as to affect intimately or personally; fully, directly, effectively. See also phrases 2.

In (or into) a position in which the intervening space is closed up, so that there is no interval; in… figurative. Of other than the literal…

In a way that involves or effects a very close connection or union of parts or elements.

With reference to alliance or union: Closely, intimately. archaic. (Very common in 16–17th centuries.)

In a congenial manner.

Similarly; in a like or related manner.

figurative. Of association, resemblance, etc.: Nearly, intimately.