In a disconcerting or troublesome manner; to one's annoyance or hurt.

Qualifying adjectives (or adverbs): To a distressing, vexing, or unsatisfactory degree; deplorably, very badly; = miserably, adv. 5.

In an irksome manner; in a way that tires, annoys, or troubles.

In an incommodious manner or degree; inconveniently, uncomfortably; troublesomely.

So as to cause trouble; annoyingly, distressingly, vexatiously; oppressively; tiresomely.

gen. In a vexatious manner; so as to cause annoyance or irritation.

In a troublesome or vexatious manner. Obsolete.

in a way that is vexatious or humiliating; embarrassingly.

In a distressing manner; distressfully, painfully.

In an annoying manner; irritatingly, tiresomely.

Annoyingly, irritatingly; confoundedly.

Now regional (chiefly Scottish and North American).

in a trying manner or degree; in the way of attempt or endeavour (rare); distressingly, painfully.