Of persons: Devoid of spiritual grace; graceless, reprobate, wicked. Obsolete.

Not in a state of grace, unregenerate; depraved, wicked, ungodly, impious.

Of a person, his or her character, actions, etc.: lacking all religious or moral sense; wicked; unprincipled.

That has broken away from restraint; abandoned, dissolute. Obsolete. rare.

Damnable, pernicious. Also in weakened sense: harmful, undesirable.

Debauched, abandoned, wicked.

Lost, abandoned, involved in ruin or perdition.

Thrown away, cast off, rejected; reprobate; ‘useless, of no value’ (Johnson).