Mental distress caused by loss, suffering, disappointment, etc.; grief, deep sadness; regret. Also: the cause of this; affliction, trouble.

Trouble, affliction; (in later use esp.) illness, disease. In early use also: harm. Obsolete.

transferred and figurative.

That which excites sorrow, grief, or pity; a grievous or piteous thing; a grief, sorrow.

A feeling or state of distress; sorrow, anguish; trouble, suffering, affliction. Obsolete (chiefly Scottish in later use).

Something which causes difficulty or distress; a source of suffering.

figurative. Chiefly in the sense (derived from various passages of Scripture): Something to be partaken of, endured or enjoyed; an experience…

Something that burdens or oppresses a person; a burden, trouble, or hardship. Obsolete.

That which causes distress; a trouble, a sorrow. Obsolete.

Something which afflicts a person; a cause of pain, misery, or distress.

Something which causes grief or suffering; an affliction.

Originally: †pain, bodily discomfort, (a) physical affliction (obsolete). In later use: mental oppression or affliction; the burden of grief…

A cause or occasion of affliction. Obsolete.

figurative. That on which something is stretched or strained; something that causes suffering or painful suspense. Cf. tenter, n.1 3.

A cause or subject of grief.

Something which annoys, troubles, or disturbs someone; a nuisance, an annoyance. Also formerly: †something which causes harm; an injury (obsolete)…

One who or that which troubles (in any sense); a disturber; an oppressor.

A person or thing that distresses or inflicts pain. Obsolete.

A source or cause of mental trouble or distress; a grief or affliction; an annoyance.

An instance of this; something inflicted, as pain, punishment, etc., or in weaker sense, an annoyance, a nuisance, a ‘visitation’.

transferred. A thing or person that gives trouble; an occasion or cause of affliction or distress.

A severe or painful trial or experience; an affliction, a trial. Obsolete.

figurative. A burden (of affliction, sin, responsibility, etc.); something which weighs down, oppresses, or impedes. Esp. in (to take) a load off…

An action, circumstance, or condition which causes extreme pain or suffering of body or mind; a source of pain, trouble, or anguish, or in weakened…

One who causes pain, suffering, etc.

figurative. A painful matter; a grievance.

figurative. Cf. ‘rub’.

figurative.

a cause of sorrow or distress; cf. sense D. 1a.

Anything which acts as a test, or severely tests character or endurance. Hence more generally: a painful, trying, or unhappy experience, esp. a…

An act of cutting up.

An unpleasurable or unpleasant experience or feeling; a source of displeasure, discomfort, or anxiety.

figurative or in figurative context. A cause of intense torment; a torturous situation.

conduct which inflicts suffering on another person without involving physical assault, esp. (U.S.) as constituting grounds for legal separation or…