At the head or top in importance; most important, influential, or active; principal, foremost, greatest. of persons.

Of a particular thing or person: first or highest in rank or importance; that is at the head of all… Of a person: having the highest rank or most…

Of a person: leading, important. Now historical.

Modifying the designation of a person: pre-eminent, chief; supremely deserving of the appellation. Now rare.