Of great import; weighty, important; serious, grave. Now rare or Obsolete.

Of great consequence; important, grave, serious. Formerly also of punishment: †severe (obsolete). Cf. high treason at treason, n. 2a.

Important, weighty; = earnest, adj. 2.

Of a formal and serious or deliberate character. Of statements, compacts, documents, etc.

Of great gravity or significance; requiring earnest thought, consideration, or application; highly important, serious, grave, momentous.

Chiefly of thought, content, etc.: serious, important, profound.

Weighty, grave; important. Obsolete.

Weighty, grave; important, significant, of great consequence.

Of an affair, activity, etc.: demanding serious consideration; weighty, important.

Grave.

figurative. Of a defect, error, etc.: fatal, vitally injurious; very serious, radical. Now rare.

Solemn; grave. Of grave consequence or effect; grave, serious, weighty, important. Obsolete.

Now esp. in unfavourable sense, of faults, evils, difficulties, responsibilities, etc.: Highly serious, formidable. Of diseases or symptoms…