adrenolyticadj.n.

Brit.

/əˌdriːnə(ʊ)ˈlɪtɪk/,

/əˌdrɛnə(ʊ)ˈlɪtɪk/, U.S.

/əˌdrinoʊˈlɪdɪk/

Origin: Formed within English, by compounding. Etymons: adreno- comb. form, -lytic comb. form.

Etymology: < adreno- comb. form + -lytic comb. form.

Pharmacology.

A. adj.

1. Destructive of the adrenal gland or its function; suppressing adrenal function, esp. hormone synthesis by the cortex.

ΚΠ

1908 W. T. Ritchie in Jrnl. Pathol. & Bacteriol. 12 140 (title) The specificity and potency of adrenolytic and thymolytic sera.

1961 L. C. Martin Clin. Endocrinol. (ed. 3) vi. 182 Phentolamine is the most reliable of the adrenolytic substances both for diagnosis of phæochromocytoma and for use during its removal.

2010 G. B. McCowage & L. Mascarenhas in W. L. Carroll & J. L. Finlay Cancer Children & Adolescents xxxii. 468/2 Higher doses [of mitotane] are needed to have an adrenolytic effect.

2. Blocking or inhibiting the effect of adrenergic nerves or neurotransmitters.

ΚΠ

1947 Proc. Soc. Exper. Biol. & Med. 66 152/2 Dibenamine..is primarily a powerful adrenolytic, but a weak sympathicolytic agent.

1962 Brit. Med. Jrnl. 13 Jan. 109/1 Since haloperidol has little adrenolytic action there are no great changes in blood-pressure.

2006 S. T. O'Rourke et al. in M. A. Creager et al. Vascular Med. v. 79/2 The adrenolytic agent, 6-hydroxytryptamine, exerts its effects by destroying adrenergic nerve endings.

B. n.

An adrenolytic substance or agent.

ΚΠ

1937 Physiol. Abstr. 21 993 Adrenolytics abolish the reaction.

1960 W. D. M. Paton in A. Rook Progr. Biol. Sci. in Relation to Dermatol. 439 The group of drugs, variously called sympatholytics, adrenolytics, or anti-adrenalines, first came to notice with Dale's researches of fifty years ago.

2006 J. P. Remington & P. Beringer Remington: Sci. & Pract. Pharmacy (ed. 21) lxxii. 1399/1 Adrenergic blocking agents sometimes are called sympatholytics, because they abolish (lyse) the response to stimulation of the sympathetic nerves, or adrenolytics, because they abolish certain responses to epinephrine.

This entry has been updated (OED Third Edition, December 2011; most recently modified version published online December 2021).

单词	adrenolytic
释义	adrenolyticadj.n. Brit. /əˌdriːnə(ʊ)ˈlɪtɪk/, /əˌdrɛnə(ʊ)ˈlɪtɪk/, U.S. /əˌdrinoʊˈlɪdɪk/ Origin: Formed within English, by compounding. Etymons: adreno- comb. form, -lytic comb. form. Etymology: < adreno- comb. form + -lytic comb. form. Pharmacology. A. adj. 1. Destructive of the adrenal gland or its function; suppressing adrenal function, esp. hormone synthesis by the cortex. ΚΠ 1908 W. T. Ritchie in Jrnl. Pathol. & Bacteriol. 12 140 (title) The specificity and potency of adrenolytic and thymolytic sera. 1961 L. C. Martin Clin. Endocrinol. (ed. 3) vi. 182 Phentolamine is the most reliable of the adrenolytic substances both for diagnosis of phæochromocytoma and for use during its removal. 2010 G. B. McCowage & L. Mascarenhas in W. L. Carroll & J. L. Finlay Cancer Children & Adolescents xxxii. 468/2 Higher doses [of mitotane] are needed to have an adrenolytic effect. 2. Blocking or inhibiting the effect of adrenergic nerves or neurotransmitters. ΚΠ 1947 Proc. Soc. Exper. Biol. & Med. 66 152/2 Dibenamine..is primarily a powerful adrenolytic, but a weak sympathicolytic agent. 1962 Brit. Med. Jrnl. 13 Jan. 109/1 Since haloperidol has little adrenolytic action there are no great changes in blood-pressure. 2006 S. T. O'Rourke et al. in M. A. Creager et al. Vascular Med. v. 79/2 The adrenolytic agent, 6-hydroxytryptamine, exerts its effects by destroying adrenergic nerve endings. B. n. An adrenolytic substance or agent. ΚΠ 1937 Physiol. Abstr. 21 993 Adrenolytics abolish the reaction. 1960 W. D. M. Paton in A. Rook Progr. Biol. Sci. in Relation to Dermatol. 439 The group of drugs, variously called sympatholytics, adrenolytics, or anti-adrenalines, first came to notice with Dale's researches of fifty years ago. 2006 J. P. Remington & P. Beringer Remington: Sci. & Pract. Pharmacy (ed. 21) lxxii. 1399/1 Adrenergic blocking agents sometimes are called sympatholytics, because they abolish (lyse) the response to stimulation of the sympathetic nerves, or adrenolytics, because they abolish certain responses to epinephrine. This entry has been updated (OED Third Edition, December 2011; most recently modified version published online December 2021). < adj.n.1908
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