C21H26N2S2, an oral tranquillizer used to treat psychological disorders
thioridazine in American English
(ˌθaiəˈrɪdəˌzin, -zɪn)
noun
Pharmacology
a phenothiazine, C21H26N2S2, used as an antipsychotic chiefly in the treatment of acute psychoses and schizophrenia
Word origin
[1955–60; thio- + (pipe)rid(ine) + azine]This word is first recorded in the period 1955–60. Other words that entered Englishat around the same time include: backgrounder, life-support, rite of passage, rollout, softwarethio- is a combining form meaning “sulfur,” used in chemical nomenclature in the namesof compounds in which part or all of the oxygen atoms have been replaced by sulfur;often used to designate sulfur analogues of oxygen compounds. Other words that usethe affix thio- include: thioacetamide, thioaldehyde, thiosinamine, thiothixene, thioxanthene
Examples of 'thioridazine' in a sentence
thioridazine
One year after discontinuation of thioridazine, her symptoms and signs did not resolve.
Masoumeh Mohebbi, Hassan Hashemi, Alireza Mahmoudi, Pasha Anvari 2017, 'Descemet's stripping-automated endothelial keratoplasty for symptomatic thioridazinedeposits in the cornea', Taiwan Journal of Ophthalmologyhttp://www.e-tjo.org/article.asp?issn=2211-5056;year=2017;volume=7;issue=1;spage=53;epage=55;aulast=Mohebbi. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The cell cycle distribution of lung cancer stem cells after thioridazine treatment was detected.
Haiying Yue, Dongning Huang, Li Qin, Zhiyong Zheng, Li Hua, Guodong Wang, Jian Huang,Haixin Huang 2016, 'Targeting Lung Cancer Stem Cells with Antipsychological Drug Thioridazine', BioMed Research Internationalhttp://dx.doi.org/10.1155/2016/6709828. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The in vivo inhibitory effect of thioridazine was also measured.
Haiying Yue, Dongning Huang, Li Qin, Zhiyong Zheng, Li Hua, Guodong Wang, Jian Huang,Haixin Huang 2016, 'Targeting Lung Cancer Stem Cells with Antipsychological Drug Thioridazine', BioMed Research Internationalhttp://dx.doi.org/10.1155/2016/6709828. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Thioridazine may represent an effective compound for treatment of susceptible and multidrug-resistant tuberculosis.
Dick van Soolingen, Rogelio Hernandez-Pando, Hector Orozco, Diana Aguilar, CecileMagis-Escurra, Leonard Amaral, Jakko van Ingen, Martin J. Boeree 2010, 'The Antipsychotic Thioridazine Shows Promising Therapeutic Activity in a Mouse Modelof Multidrug-Resistant Tuberculosis', PLoS ONE10.1371/journal.pone.0012640. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Therefore, we investigated whether combined treatment with thioridazine and curcumin induces apoptosis.
Seung Un Seo, Tae Hwan Kim, Dong Eun Kim, Kyoung-jin Min, Taeg Kyu Kwon 2017, 'NOX4-mediated ROS production induces apoptotic cell death via down-regulation of c-FLIPand Mcl-1 expression in combined treatment with thioridazine and curcumin', Redox Biologyhttp://www.sciencedirect.com/science/article/pii/S2213231717302902. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We found that thioridazine could dramatically inhibit sphere formation of lung cancer stem cells.
Haiying Yue, Dongning Huang, Li Qin, Zhiyong Zheng, Li Hua, Guodong Wang, Jian Huang,Haixin Huang 2016, 'Targeting Lung Cancer Stem Cells with Antipsychological Drug Thioridazine', BioMed Research Internationalhttp://dx.doi.org/10.1155/2016/6709828. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Selected strains were whole-genome sequenced to find mutations causing thioridazine resistance.
Claes Søndergaard Wassmann, Lars Christian Lund, Mette Thorsing, Sabrina Prehn Lauritzen,Hans Jørn Kolmos, Birgitte Haahr Kallipolitis, Janne Kudsk Klitgaard 2018, 'Molecular mechanisms of thioridazine resistance in Staphylococcus aureus', PLOS ONE10.1371/journal.pone.0201767. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
She had been taking thioridazine (100 mg/day for 1 year) for a psychiatric disorder.
Masoumeh Mohebbi, Hassan Hashemi, Alireza Mahmoudi, Pasha Anvari 2017, 'Descemet's stripping-automated endothelial keratoplasty for symptomatic thioridazinedeposits in the cornea', Taiwan Journal of Ophthalmologyhttp://www.e-tjo.org/article.asp?issn=2211-5056;year=2017;volume=7;issue=1;spage=53;epage=55;aulast=Mohebbi. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)