the process by which the atoms of a compound become a closed ring
cyclization in American English
(ˌsaikləˈzeiʃən, ˌsɪklə-)
noun
Chemistry
the formation of a ring or rings
Word origin
[1905–10; cyclize + -ation]This word is first recorded in the period 1905–10. Other words that entered Englishat around the same time include: cadre, overcall, persona, stabilizer, white list-ation is used to form nouns from stems ending in -ate (separation) and, on this model, to form nouns from stems of other origin (starvation). Other words that use the affix -ation include: capitalization, neutralization, pagination, sensitization, transportation
Examples of 'cyclization' in a sentence
cyclization
However, combined 1,2-constriction by cyclization has only been tested with one compound.
Vignir Isberg, James Paine, Sebastian Leth-Petersen, Jesper L. Kristensen, David E.Gloriam 2013, 'Structure-Activity Relationships of Constrained Phenylethylamine Ligands for the Serotonin5-HT2 Receptors', PLoS ONE10.1371/journal.pone.0078515. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Initial mechanistic experiments suggest a reaction pathway involving oxygen transfer followed by cyclization.
Dimitra Kontokosta, Daniel S. Mueller, Dong-Liang Mo, Wiktoria H. Pace, Rachel A.Simpson, Laura L. Anderson 2015, 'Copper-mediated synthesis of N-alkenyl-α,β-unsaturated nitrones and their conversionto tri- and tetrasubstituted pyridines', Beilstein Journal of Organic Chemistryhttps://doi.org/10.3762/bjoc.11.226. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These constructs differ in the length and amino acid composition of the cyclization region.
Frank H Schumann, Ranjani eVaradan, Praveen Pudiavettil Tayakuniyil, Jennifer HallGrossman, Julio A Camarero, Julio A Camarero, David eFushman 2015, 'Changing the topology of protein backbone: the effect of backbone cyclization on thestructure and dynamics of a SH3 domain', Frontiers in Chemistryhttp://journal.frontiersin.org/Journal/10.3389/fchem.2015.00026/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The mechanism and selectivity of a bicyclic hydantoin formation by selenium-induced cyclization are investigated.
Biljana M. Šmit, Radoslav Z. Pavlović, Dejan A. Milenković, Zoran S. Marković 2015, 'Mechanism, kinetics and selectivity of selenocyclization of 5-alkenylhydantoins: anexperimental and computational study', Beilstein Journal of Organic Chemistryhttps://doi.org/10.3762/bjoc.11.200. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Cyclization of acyclic lycopene by cyclases marks an important regulatory point in carotenoid biosynthesis.
Yong M. Lao, Yong M. Lao, Hui Jin, Hui Jin, Hui Jin, Jin Zhou, Jin Zhou, Huai J. Zhang,Zhong H. Cai, Zhong H. Cai 2017, 'Functional Characterization of a Missing Branch Component in Haematococcus pluvialisfor Control of Algal Carotenoid Biosynthesis', Frontiers in Plant Sciencehttp://journal.frontiersin.org/article/10.3389/fpls.2017.01341/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The radical alkylarylation reaction proceeds through a sequence of alkylation and intramolecular cyclization.
Ping Qian, Bingnan Du, Wei Jiao, Haibo Mei, Jianlin Han, Yi Pan 2016, 'Cascade alkylarylation of substituted N-allylbenzamides for the construction of dihydroisoquinolin-1(2H)-onesand isoquinoline-1,3(2H,4H)-diones', Beilstein Journal of Organic Chemistryhttps://doi.org/10.3762/bjoc.12.32. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Novel boratetraazapentalenes were synthesized via a cyclization reaction with boron trifluoride.
Martin Matschke, Rainer Beckert 2007, 'Multi-step Redox Systems with NIR-Fluorescence Based on 4H-Imidazoles', Moleculeshttp://www.mdpi.com/1420-3049/12/4/723/. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The reaction proceeds via base-promoted propargyl–allenyl rearrangement followed bycyclization and allyl migration.
Jinzhong Yao, Yajie Xie, Lianpeng Zhang, Yujin Li, Hongwei Zhou 2017, 'Synthesis of benzothiophene and indole derivatives through metal-free propargyl–allenerearrangement and allyl migration', Beilstein Journal of Organic Chemistryhttps://doi.org/10.3762/bjoc.13.181. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This was followed by the cyclization of the linear tetrapeptide fragment under alkaline conditions.
Rajiv Dahiya, Suresh Kumar, Sukhbir Lal Khokra, Sheeba Varghese Gupta, VijaykumarB. Sutariya, Deepak Bhatia, Ajay Sharma, Shamjeet Singh, Sandeep Maharaj 2018, 'Toward the Synthesis and Improved Biopotential of an N-methylated Analog of a Proline-RichCyclic Tetrapeptide from Marine Bacteria', Marine Drugshttp://www.mdpi.com/1660-3397/16/9/305. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)