the formation of a cyclic compound by the addition reaction of unsaturated molecules
Word origin
[1960–65; cyclo- + addition]This word is first recorded in the period 1960–65. Other words that entered Englishat around the same time include: Pap test, deinstitutionalize, disco, power play, zip codecyclo- is a combining form meaning “cycle,” used in the formation of compound words. Otherwords that use the affix cyclo- include: cyclohexylamine, cyclometer, cyclostome, cyclostyle, cyclothymia
Examples of 'cycloaddition' in a sentence
cycloaddition
Several compounds related to helminthosporic acid (3) were synthesized via the [3+4] cycloaddition.
Barbosa Luiz Cláudio de Almeida, Demuner Antônio Jacinto, Maltha Célia Regina Álvares,Silva Patrícia Silvana da, Silva Antônio Alberto da 2003, 'Síntese e avaliação da atividade fitotóxica de novos análogos oxigenados do ácidohelmintospórico', Química Novahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422003000500006. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
It was found that cycloaddition occurs diastereoselectively at the generated center.
Alexander Anis'kov, Irina Klochkova, Roman Tumskiy, Alevtina Yegorova 2017, 'A Diastereoselective Synthesis of Dispiro[oxindole-cyclohexanone]pyrrolidines by 1,3-DipolarCycloaddition', Moleculeshttps://www.mdpi.com/1420-3049/22/12/2134. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In both strategies, intramolecular cycloaddition reactions are the key step.
Amra Ibric, Stefan Eckerstorfer, Martin Eder, Ivan Louko, Leopold Tunjic, Petra Heffeter,Hemma Henrike Schueffl, Brigitte Marian, Norbert Haider 2019, 'Position-Selective Synthesis and Biological Evaluation of Four Isomeric A-Ring AminoDerivatives of the Alkaloid Luotonin A', Moleculeshttps://www.mdpi.com/1420-3049/24/4/716. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The cations and anions of ionic liquids show a synergistic effect on the cycloaddition reactions.
Flora T.T. Ng, Jinquan Wang, Jian Sun, Weiguo Cheng, Qian Su 2013, 'Ionic Liquids: The Synergistic Catalytic Effect in the Synthesis of Cyclic Carbonates',Catalystshttp://www.mdpi.com/2073-4344/3/4/878. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
An efficient synthesis of functionalized spiropyrrolizidine oxindoles via a three-component tandem cycloaddition has been achieved.
Tai-Ran Kang, Ting-Ting Yan, Jie Liu, Hong-Bao Sun, Yong-Mei Xie, Yu-Qin Yao 2011, 'Facile Synthesis of Functionalized Spiropyrrolizidine Oxindoles via a Three-ComponentTandem Cycloaddition Reaction', Moleculeshttp://www.mdpi.com/1420-3049/16/10/8745/. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The cycloaddition of pyridinium ylides with alkynes was investigated under mild conditions.
Simon Bonte, Ioana Otilia Ghinea, Rodica Dinica, Isabelle Baussanne, Martine Demeunynck 2016, 'Investigation of the Pyridinium Ylide—Alkyne Cycloaddition as a Fluorogenic CouplingReaction', Moleculeshttp://www.mdpi.com/1420-3049/21/3/332. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The 1,3-dipolar cycloaddition of nitrile oxides to 1-cyanoenamines gives 5-aminoisoxazoles regioselectively.
Aïcha Derdour, Michel Vaultier, Amar Saad 2004, 'One Step Regioselective Synthesis of 5-Aminoisoxazoles from Nitrile Oxides and α-Cyanoenamines',Moleculeshttp://www.mdpi.com/1420-3049/9/7/527/. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
By intramolecular [2+2]-cycloaddition, this hexatriene system gives the phototranspositionproducts.
Šindler-Kulyk, M., Škorić, I. 2007, 'Svjetlom do heteropolicikličkih spojeva; Reakcije supstituiranih furostilbena', Kemija u Industrijihttp://pierre.fkit.hr/hdki/kui/vol56/broj03/135.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)