any substance or treatment that inhibits cell growth
cytostatic in American English
(ˌsaitəˈstætɪk)
adjective
1.
inhibiting cell growth and division
noun
2.
any substance that inhibits cell growth and division
Word origin
[cyto- + static]cyto- is a combining form meaning “cell,” used in the formation of compound words. Otherwords that use the affix cyto- include: cytokinin, cytopathic, cytopathogenic, cytosol, endocytobiology
Examples of 'cytostatic' in a sentence
cytostatic
Interestingly, apigenin itself exerted cytostatic activity because of its ability to induce cell cycle arrest.
Sung Min Ju, Jun Gue Kang, Jun Sang Bae, Hyun Ock Pae, Yeoung Su Lyu, Byung Hun Jeon 2015, 'The Flavonoid Apigenin Ameliorates Cisplatin-Induced Nephrotoxicity through Reductionof p53 Activation and Promotion of PI3K/Akt Pathway in Human Renal Proximal TubularEpithelial Cells', Evidence-Based Complementary and Alternative Medicinehttp://dx.doi.org/10.1155/2015/186436. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This response was consistent with a cytostatic effect, because no evidence of apoptosis was detected.
Paola Ulivi, Wainer Zoli, Francesco Fabbri, Giovanni Brigliadori, Luca Ricotti, AnnaTesei, Marco Rosetti, Michelandrea De Cesare, Giovanni L. Beretta, Elisabetta Corna,Rosanna Supino, Franco Zunino 2005, 'Cellular Basis of Antiproliferative and Antitumor Activity of the Novel CamptothecinDerivative, Gimatecan, in Bladder Carcinoma Models', Neoplasia: An International Journal for Oncology Researchhttp://www.sciencedirect.com/science/article/pii/S1476558605800168. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In addition, autophagy interpheres with cell cycle progression, de facto exerting a cytostatic activity.
Mariachiara Buccarelli, Matteo Marconi, Simone Pacioni, Ivana De Pascalis, QuintinoGiorgio D'Alessandris, Maurizio Martini, Barbara Ascione, Walter Malorni, Luigi MariaLarocca, Roberto Pallini, Lucia Ricci-Vitiani, Paola Matarrese 2018, 'Inhibition of autophagy increases susceptibility of glioblastoma stem cells to temozolomideby igniting ferroptosis', Cell Death and Diseasehttp://link.springer.com/article/10.1038/s41419-018-0864-7. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Compounds 5a-h were evaluated for their cytostatic andantiviral activities.
Mladen Mintas, Erik De Clercq, Jan Balzarini, Krešimir Pavelic, Marijeta Kralj,Katja Ester, Silvana Raic-Malic, Branka Zorc, Zrinka Rajic 2006, 'Hydantoin Derivatives of L- and D-amino acids: Synthesis and Evaluation of Their Antiviraland Antitumoral Activity', Moleculeshttp://www.mdpi.com/1420-3049/11/11/837/. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Propolis treatment had no effects on apoptosis, demonstrating a cytostatic action.
Kleiton Silva Borges, María Sol Brassesco, Carlos Alberto Scrideli, Ademilson EspencerEgea Soares, Luiz Gonzaga Tone 2011, 'Antiproliferative effects of Tubi-bee propolis in glioblastoma cell lines', Genetics and Molecular Biologyhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000200024. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Regarding antiproliferative activity, the extract demonstrated cytostatic potential in all strains tested.
Rennaly de Freitas Lima, Érika Ponchet Alves, Pedro Luiz Rosalen, Ana Lúcia TascaGois Ruiz, Marta Cristina Teixeira Duarte, Vivian Fernandes Furletti Góes, Ana CláudiaDantas de Medeiros, Jozinete Vieira Pereira, Gustavo Pina Godoy, Edja Maria Melo deBrito Costa 2014, 'Antimicrobial and Antiproliferative Potential of Anadenanthera colubrina (Vell.) Brenan',Evidence-Based Complementary and Alternative Medicinehttp://dx.doi.org/10.1155/2014/802696. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Conventional cytostatic cancer treatments rarely result in the complete eradication of tumor cells.
Kathrin Pfarr, Corina Danciu, Olga Arlt, Christina Neske, Cristina Dehelean, JosefM Pfeilschifter, Heinfried H Radeke 2015, 'Simultaneous and dose dependent melanoma cytotoxic and immune stimulatory activityof betulin.', PLoS ONEhttp://europepmc.org/articles/PMC4355578?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Our results indicated a significant cytotoxic or cytostatic effect on human peripheral blood lymphocytes.
Michalková R., Šiviková K., Galdíková M. 2018, 'Analysis of Sister Chromatid Exchanges and Proliferation of Human Peripheral BloodLymphocytes Exposed to Epoxiconazole', Folia Veterinariahttp://www.degruyter.com/view/j/fv.2018.62.issue-3/fv-2018-0026/fv-2018-0026.xml?format=INT. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)