It is a safe bet that all cancers are multigenic in origin.
2.
of or relating to a group of genes with similar nucleotide sequences (multigenes)
Examples of 'multigenic' in a sentence
multigenic
Responses were often multigenic and occasionally persisted up to one year post vaccination.
Sandhya Vasan, Sarah J Schlesinger, Zhiwei Chen, Arlene Hurley, Angela Lombardo, SoeThan, Phumla Adesanya, Catherine Bunce, Mark Boaz, Rosanne Boyle, Eddy Sayeed, LornaClark, Daniel Dugin, Mar Boente-Carrera, Claudia Schmidt, Qing Fang, LeiBa, YaoxingHuang, Gerasimos J Zaharatos, David F Gardiner, Marina Caskey, Laura Seamons, MartinHo, Len Dally, Carol Smith, Josephine Cox, Dilbinder Gill, Jill Gilmour, Michael CKeefer, Patricia Fast, David D Ho 2010, 'Phase 1 safety and immunogenicity evaluation of ADMVA, a multigenic, modified vacciniaAnkara-HIV-1 B'/C candidate vaccine.', PLoS ONEhttp://europepmc.org/articles/PMC2810329?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Drought being a major challenge for crop productivity and yield affects multigenic and quantitative traits.
Prateek Tripathi, Roel C. Rabara, Qingxi J. Shen, Paul J. Rushton 2015, 'Transcriptomics analyses of soybean leaf and root samples during water-deficit', Genomics Datahttp://www.sciencedirect.com/science/article/pii/S2213596015000999. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Microarrays can be used as multigenic predictors of patient response, but probe selection remains problematic.
Coutant Charles, Yan Kai, Guinot Philippe, Charles Benoît, Horta Euler, Incitti Roberto,Natowicz René, Andre Fabrice, Pusztai Lajos, Rouzier Roman 2008, 'Prediction of the outcome of preoperative chemotherapy in breast cancer using DNAprobes that provide information on both complete and incomplete responses', BMC Bioinformaticshttp://www.biomedcentral.com/1471-2105/9/149. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
But for traits that are quantitative and multigenic, marker assisted selection may not be practical.
Burton Joseph W., Miranda Lilian 2013, 'Soybean improvement: Achievements and challenges', Ratarstvo i Povrtarstvohttp://scindeks-clanci.ceon.rs/data/pdf/1821-3944/2013/1821-39441302044B.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The phylogenetic method defines 5 groups of epiplasmins in the multigenic family.
Ravet Viviane, Viguès Bernard, Coffe Gérard, Bricheux Geneviève, Pomel Sébastien,Damaj Raghida, Bouchard Philippe 2009, 'Cross-study analysis of genomic data defines the ciliate multigenic epiplasmin family:strategies for functional analysis in Paramecium tetraurelia', BMC Evolutionary Biologyhttp://www.biomedcentral.com/1471-2148/9/125. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Do such mutations contribute to multigenic risk in multiple pathologies?
Stuart J. Mires 2013, 'Fibroblast Growth Factor (FGF) Receptor Mutations: A Pathway to Understanding MultigenicRisk in Disease?', International Journal of Medical Studentshttp://www.ijms.info/ojs/index.php/IJMS/article/view/50. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Multigenic traits are very common in plants and cause diversity.
Mihai Miclaus, Jian-Hong Xu, Joachim Messing 2011, 'Differential gene expression and epiregulation of alpha zein gene copies in maizehaplotypes.', PLoS Geneticshttp://europepmc.org/articles/PMC3121756?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The potential for multigenic interactions contributing to human dilated cardiomyopathy remains poorly understood.
Siobhan Simpson, Jennifer Edwards, Richard D. Emes, Malcolm A. Cobb, Nigel P. Mongan,Catrin S. Rutland 2015, 'A predictive model for canine dilated cardiomyopathy—a meta-analysis of Doberman Pinscherdata', PeerJhttps://peerj.com/articles/842.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In this study, we aim to identify potential novel molecular targets that contribute to the multigenic trait "anxiety".
Ludwig Czibere, Laura A Baur, Anke Wittmann, Katja Gemmeke, Andrea Steiner, PeterWeber, Benno Pütz, Nafees Ahmad, Mirjam Bunck, Cornelia Graf, Regina Widner, ClaudiaKühne, Markus Panhuysen, Boris Hambsch, Gabriele Rieder, Thomas Reinheckel, ChristophPeters, Florian Holsboer, Rainer Landgraf, Jan M Deussing 2011, 'Profiling trait anxiety: transcriptome analysis reveals cathepsin B (Ctsb) as a novelcandidate gene for emotionality in mice.', PLoS ONEhttp://europepmc.org/articles/PMC3163650?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)