an enzyme that catalyses the removal of carbon dioxide from a compound
decarboxylase in American English
(ˈdikɑːrˈbɑksəˌleis, -ˌleiz)
noun
Biochemistry
any of the class of enzymes that catalyze the release of carbon dioxide from the carboxyl group of certain organic acids
Also called: carboxylase
Word origin
[1935–40; decarboxyl(ate) + -ase]This word is first recorded in the period 1935–40. Other words that entered Englishat around the same time include: Arts and Crafts Movement, Rhodesian ridgeback, blitz, gangbuster, roomette-ase is a suffix used in the names of enzymes. Other words that use the affix -ase include: hyaluronidase, lipase, peroxidase, reverse transcriptase, zymase
Examples of 'decarboxylase' in a sentence
decarboxylase
Only pyruvate was the specific substrate for pyruvate decarboxylase.
Dorota Kręgiel, Wojciech Ambroziak, Joanna Berłowska 2009, 'Pyruvate Decarboxylase Activity Assay in situ of Different Industrial Yeast Strains',Food Technology and Biotechnologyhttp://hrcak.srce.hr/file/52630. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In addition, the data suggest an unexpected off-target effect on glutamate decarboxylase.
Henrik Antti, Magnus Sellstedt 2018, 'Metabolic effects of an aspartate aminotransferase-inhibitor on two T-cell lines.',PLoS ONEhttp://europepmc.org/articles/PMC6285999?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We explored the in vitro/in vivo effects of well-characterized monoclonal glutamate decarboxylase antibodies.
Mario U Manto, Jerome eHonorat, Christiane Susanne Hampe, Rafael eGuerra-Narbona,Juan Carlos eLópez Ramos, José M Delgado-García, Fumihito eSaitow, Hidenori eSuzuki,Yuchio eYanagawa, Hidehiro eMizusawa, Hiroshi eMitoma 2015, 'Disease-specific monoclonal antibodies targeting glutamate decarboxylase impair GABAergicneurotransmission and affect motor learning and behavioral functions', Frontiers in Behavioral Neurosciencehttp://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00078/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This process starts with arginine decarboxylase that converts arginine to agmatine.
Bartosz Sekula, Zbigniew Dauter 2019, 'Structural Study of Agmatine Iminohydrolase From Medicago truncatula, the Second Enzymeof the Agmatine Route of Putrescine Biosynthesis in Plants', Frontiers in Plant Sciencehttps://www.frontiersin.org/article/10.3389/fpls.2019.00320/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Subculture and prolonged incubation resulted in positive results for ornithine decarboxylase and for motility.
Verschraegen Gerda, Vandecandelaere Patricia, Wauters Georges, De Baere Thierry, ClaeysGeert, Muylaert An, Vaneechoutte Mario 2004, 'Extended-Spectrum β-lactamase (ESBL) producing Enterobacter aerogenes phenotypicallymisidentified as Klebsiella pneumoniae or K. terrigena', BMC Microbiologyhttp://www.biomedcentral.com/1471-2180/4/49. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The amino acid decarboxylase activities were detected negative for histidine, tyrosine, and ornithine.
Başar Uymaz Tezel 2019, 'Preliminary In Vitro Evaluation of the Probiotic Potential of the BacteriocinogenicStrain Enterococcus lactis PMD74 Isolated from Ezine Cheese', Journal of Food Qualityhttp://dx.doi.org/10.1155/2019/4693513. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This decarboxylase efficiently catalyzes tyrosine to tyramine conversion.
Rong Wang, Xiaokang Han, Sheng Xu, Bing Xia, Yumei Jiang, Yong Xue, Ren Wang 2019, 'Cloning and characterization of a tyrosine decarboxylase involved in the biosynthesisof galanthamine in Lycoris aurea', PeerJhttps://peerj.com/articles/6729.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Antibodies against glutamate decarboxylase were less specific (70%) and had very lowsensitivity (58,3%).
Leila S. Sozaeva, Lubov I. Zilberman, Galina N. Svetlova, Ekaterina A. Andrianova,Maria A. Kareva, Olga N. Ivanova, Svetlana M. Stepanova, Larisa V. Savelyeva, AlexandrY. Mayorov, Ekaterina A. Troshina, Elizaveta M. Orlova, Eystein S. Husebye, ValentinaA. Peterkova 2018, 'Clinical and immunological characteristics of diabetes mellitus in patients with autoimmunepolyglandular syndrome type 1 in Russia', Saharnyj Diabethttps://endojournals.ru/index.php/dia/article/viewFile/9347/7161. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
None of the strains contained decarboxylase genes, which are required for histamine and tyramine production.
Jong-Hoon Lee, Sojeong Heo, Do-Won Jeong 2018, 'Genomic insights into Staphylococcus equorum KS1039 as a potential starter culturefor the fermentation of high-salt foods', BMC Genomicshttp://link.springer.com/article/10.1186/s12864-018-4532-1. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Ethanol reduced the activities of uroporphyrinogen decarboxylase, delta-aminolevulinate dehydraseand ferrochelatase.
M.C. Ríos de Molina, M.B. Mazzetti, M. Galigniana, C. Aldonatti, J.M. Tomio, L.C.San Martín de Viale 2002, 'The decrease in uroporphyrinogen decarboxylase activity induced by ethanol predisposesrats to the development of porphyria and accelerates xenobiotic-triggered porphyria,regardless of hepatic damage', Brazilian Journal of Medical and Biological Researchhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001100004. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)