any of the filaments of protein molecules that overlap to form the sarcomere of a myofibril, composed of either myosin (thick filament) or actin (thin filament)
myofilament in American English
(ˌmaiəˈfɪləmənt)
noun
Biology
a threadlike filament of actin or myosin that is a component of a myofibril
Word origin
[1945–50; myo- + filament]
Examples of 'myofilament' in a sentence
myofilament
Furthermore, cellular and myofilament-level adaptations are related to diminished whole muscle and whole body performance.
Mark Stuart Miller, Damien Mark Callahan, Michael J Toth, Michael J Toth 2014, 'Skeletal muscle myofilament adaptations to aging, disease and disuse and their effectson whole muscle performance in older adult humans', Frontiers in Physiologyhttp://journal.frontiersin.org/Journal/10.3389/fphys.2014.00369/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Here, we tested the hypothesis that acute exercise changes titin phosphorylation and modifies myofilament stiffness.
Anna Eliane Müller, Matthias eKreiner, Sebastian eKötter, Philipp eLassak, WilhelmeBloch, Frank eSuhr, Martina eKrüger 2014, 'Acute exercise modifies titin phosphorylation and increases cardiac myofilament stiffness',Frontiers in Physiologyhttp://journal.frontiersin.org/Journal/10.3389/fphys.2014.00449/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Changes in myofilament activation did not translate into alterations in whole heart function.
Justyna Kulpa, Nirmala Chinnappareddy, W Glen Pyle 2012, 'Rapid changes in cardiac myofilament function following the acute activation of estrogenreceptor-alpha.', PLoS ONEhttp://europepmc.org/articles/PMC3408454?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In sham hearts, no significant transmural differences were observed in myofilament function or protein phosphorylation.
Jolanda evan der Velden, Daphne eMerkus, Vincent ede Beer, Nazha eHamdani, WolfgangeLinke, Nicky M Boontje, Ger JM Stienen, Dirk J Duncker 2011, 'Transmural heterogeneity of myofilament function and sarcomeric protein phosphorylationin remodelled myocardium of pigs with a recent myocardial infarction', Frontiers in Physiologyhttp://journal.frontiersin.org/Journal/10.3389/fphys.2011.00083/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Troponins are thin myofilament proteins that regulate the contraction of cardiac and skeletal muscle.
Andrew Connelly, Iain N. Findlay, Caroline J. Coats 2016, 'Measurement of troponin in cardiomyopathies', Cardiogeneticshttp://www.pagepressjournals.org/index.php/cardiogen/article/view/6306. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The ultrastructure was clear, and the arrangement of myofilament was more regular.
Chen H, Dong Y, He X, Li J, Wang J 2018, 'Paeoniflorin improves cardiac function and decreases adverse postinfarction left ventricularremodeling in a rat model of acute myocardial infarction', Drug Design, Development and Therapyhttps://www.dovepress.com/paeoniflorin-improves-cardiac-function-and-decreases-adverse-postinfar-peer-reviewed-article-DDDT. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Dynamic features are dominated by myofilament cooperativity that stem from different sources.
Sampath K Gollapudi, Murali Chandra 2016, 'Dilated cardiomyopathy mutation (R134W) in mouse cardiac troponin T induces greatercontractile deficits against α-myosin heavy chain than against β-myosin heavy chain',Frontiers in Physiologyhttp://journal.frontiersin.org/Journal/10.3389/fphys.2016.00443/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Estrogens have well-recognized and complex cardiovascular effects, including altering myocardial contractility through changes in myofilament function.
Justyna Kulpa, Nirmala Chinnappareddy, W Glen Pyle 2012, 'Rapid changes in cardiac myofilament function following the acute activation of estrogenreceptor-alpha.', PLoS ONEhttp://europepmc.org/articles/PMC3408454?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Here, we review the facts of cardiac myofilament contractility in patients with cardiomyopathy and heart failure.
Petr G. Vikhorev, Natalia N. Vikhoreva 2018, 'Cardiomyopathies and Related Changes in Contractility of Human Heart Muscle', International Journal of Molecular Scienceshttp://www.mdpi.com/1422-0067/19/8/2234. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)