Myopathies represent a heterogeneous group of diseases with distinct clinical and morphological characteristics.
CGN Back, PCB Oliveira, SMG Mattiello-Rosa, CFR Sobreira, EZ Martinez, AC Mattiello-Sverzut 2008, 'Correlação entre a proporção de fibras rápidas do músculo bíceps braquial e o torquerelativo da flexão do cotovelo em sujeitos com hipótese clínica de miopatia Correlationbetween the proportion of fast fibers in the biceps brachii muscle and the relativetorque during elbow flexion in subjects with clinical hypothesis of myopathy', Brazilian Journal of Physical Therapyhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-35552008000200006. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Inherited myopathies are a heterogeneous group of disabling disorders with still barely understood pathological mechanisms.
Osorio Abath Neto, Olivier Tassy, Valérie Biancalana, Edmar Zanoteli, Olivier Pourquié,Jocelyn Laporte 2014, 'Integrative Data Mining Highlights Candidate Genes for Monogenic Myopathies', PLoS ONE10.1371/journal.pone.0110888. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Biomaterial-guided regeneration represents a novel approach for the treatment of myopathies.
D Kuraitis, D Ebadi, P Zhang, E Rizzuto, B Vulesevic, DT Padavan, A Al Madhoun, KAMcEwan, T Sofrenovic, K Nicholson, SC Whitman, TG Mesana, IS Skerjanc, A Musarò, MRuel, EJ Suuronen 2012, 'Injected matrix stimulates myogenesis and regeneration of mouse skeletal muscle afterischaemic injury', European Cells & Materialshttp://www.ecmjournal.org/journal/papers/vol024/pdf/v024a13.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Various autoantibodies are seen in idiopathic inflammatory myopathies.
Hajime Yoshifuji 2015, 'Biomarkers and Autoantibodies of Interstitial Lung Disease with Idiopathic InflammatoryMyopathies', Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicinehttps://doi.org/10.4137/CCRPM.S36748. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These approaches will aid in the development of novel therapeutic targeting strategies for inflammation-induced myopathies.
Patsie ePolly, Timothy Chiat-Choon Tan, Timothy Chiat-Choon Tan, Timothy Chiat-ChoonTan 2014, 'The Role of Vitamin D in Skeletal and Cardiac Muscle Function', Frontiers in Physiologyhttp://journal.frontiersin.org/Journal/10.3389/fphys.2014.00145/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This could be of significant importance for the treatment of myopathies using regenerative cell-based therapies.
Alice M C van Gemert, Annelies M A van der Laan, Gonneke S K Pilgram, Lee G Fradkin,Jasprina N Noordermeer, Hans J Tanke, Carolina R Jost 2009, 'In vivo monitoring of mRNA movement in Drosophila body wall muscle cells reveals thepresence of myofiber domains.', PLoS ONEhttp://europepmc.org/articles/PMC2722729?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Myopathies include inherited and non-inherited/acquired neuromuscular pathologies characterized by muscular degeneration and weakness.
Tania Gamberi, Francesca Magherini, Tania Fiaschi 2019, 'Adiponectin in Myopathies', International Journal of Molecular Scienceshttps://www.mdpi.com/1422-0067/20/7/1544. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Inflammatory myopathies are a rare group of diseases characterized by proximal weakness.
Juan Pablo Rivas-de Noriega, Javier Andrés Galnares-Olalde, Javier Zúñiga-Varga, JuanPablo Herrera-Félix, Marco Antonio Alegría-Loyola, Alonso Turrent-Carriles 2018, 'Utility of [18F] Fluorodeoxyglucose Positron Emission Tomography/Computed TomographyScan in Inflammatory Myopathies: Case Report and Literature Review', Case Reports in Rheumatologyhttp://dx.doi.org/10.1155/2018/8398453. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Dusty cores were not observed in other core myopathies and centronuclear myopathies.
Matteo Garibaldi, John Rendu, Julie Brocard, Emmanuelle Lacene, Julien Fauré, GuyBrochier, Maud Beuvin, Clemence Labasse, Angeline Madelaine, Edoardo Malfatti, JorgeAlfredo Bevilacqua, Fabiana Lubieniecki, Soledad Monges, Ana Lia Taratuto, JocelynLaporte, Isabelle Marty, Giovanni Antonini, Norma Beatriz Romero 2019, '‘Dusty core disease' (DuCD): expanding morphological spectrum of RYR1 recessive myopathies',Acta Neuropathologica Communicationshttp://link.springer.com/article/10.1186/s40478-018-0655-5. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)