the removal or destruction of the myelin sheath surrounding a nerve
demyelination in American English
(ˌdimaiələˈneiʃən)
noun
loss of myelin from the nerve sheaths, as in multiple sclerosis
Word origin
[1930–35; de- + myelination]This word is first recorded in the period 1930–35. Other words that entered Englishat around the same time include: DNA, boondoggle, logical positivism, saddle stitch, videode- is a prefix occurring in loanwords from Latin (decide); also used to indicate privation, removal, and separation (dehumidify), negation (demerit; derange), descent (degrade; deduce), reversal (detract), or intensity (decompound)
Examples of 'demyelination' in a sentence
demyelination
Here we describe a larval zebrafish model of demyelination and remyelination.
Marja J. Karttunen, Tim Czopka, Marieke Goedhart, Jason J. Early, David A. Lyons 2017, 'Regeneration of myelin sheaths of normal length and thickness in the zebrafish CNScorrelates with growth of axons in caliber', PLOS ONE10.1371/journal.pone.0178058. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The symptoms may be caused by inflammatory demyelination, axonal degeneration, or both.
Krestetska S.L., Krestetsky N.G. 2012, 'Microbiological and immunological aspects of Guillain-Barré syndrome', Anali Mečnikìvsʹkogo Institutuhttp://archive.nbuv.gov.ua/e-journals/AMI/2012_1/12kslmia.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Demyelination and cavitation were observed in the white matter.
Yong Sun, Li-hai Zhang, Yang-mu Fu, Zhi-rui Li, Jian-heng Liu, Jiang Peng, Bin Liu,Pei-fu Tang 2016, 'Establishment of a rat model of chronic thoracolumbar cord compression with a flatplastic screw', Neural Regeneration Researchhttp://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=6;spage=963;epage=970;aulast=Sun. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Demyelination with axonal degeneration caused by occupational n-hexane exposure was strongly suspected.
Jo-Hui Pan, Chiung-Yu Peng, Chung-Ting Lo, Chia-Yen Dai, Chao-Ling Wang, Hung-Yi Chuang 2017, 'n-Hexane intoxication in a Chinese medicine pharmaceutical plant: a case report',Journal of Medical Case Reportshttp://link.springer.com/article/10.1186/s13256-017-1280-9. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Flow cytometry and histopathology were performed to assess inflammatory cell populations and demyelination.
Wendy Atkinson, Reza Forghani, Gregory R. Wojtkiewicz, Benjamin Pulli, Yoshiko Iwamoto,Takuya Ueno, Peter Waterman, Jessica Truelove, Rahmi Oklu, John W. Chen 2012, 'Ligation of the Jugular Veins Does Not Result in Brain Inflammation or Demyelinationin Mice', PLoS ONE10.1371/journal.pone.0033671. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We therefore tested whether demyelination of the fimbria produces deficits in active place avoidance.
Natalia M Grin'kina, Samah G Abdel-Baki, Peter J Bergold 2013, 'Reversible behavioral deficits in rats during a cycle of demyelination-remyelinationof the fimbria.', PLoS ONEhttp://europepmc.org/articles/PMC3551947?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In particular, evidence suggests the presence of segmental demyelination and remyelination of axons.
Abby Scurfield, David C Latimer 2018, 'A computational study of the impact of inhomogeneous internodal lengths on conductionvelocity in myelinated neurons.', PLoS ONEhttp://europepmc.org/articles/PMC5766232?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Extrapyramidal demyelination occurs in 10% of cases.
Waseem R Dar, Najeeb U Sofi, Muzamil Latief, Imtiyaz A Dar, Moomin Hussain 2015, 'Secondary parkinsonism due to osmotic demyelination syndrome: a case report', The Egyptian Journal of Internal Medicinehttp://www.esim.eg.net/article.asp?issn=1110-7782;year=2015;volume=27;issue=4;spage=157;epage=159;aulast=Dar. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Both treatments attenuated axonal loss and demyelination, improved neuronal survival, and produced functional improvement.
Hong eJiang, Ke-Wei eTian, Fan eZhang, Beibei eWang, Shu eHan 2016, 'Reg-2, a downstream signaling protein in the ciliary neurotrophic factor survivalpathway, alleviates experimental autoimmune encephalomyelitis', Frontiers in Neuroanatomyhttp://journal.frontiersin.org/Journal/10.3389/fnana.2016.00050/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
There was no evidence of demyelination, autoimmunity or sarcoidosis.
Samra Amrit, Ramtahal Jason 2012, 'Recurrent subacute visual loss presenting in a 52-year-old Caucasian woman with chronicrelapsing inflammatory optic neuropathy: a case report', Journal of Medical Case Reportshttp://www.jmedicalcasereports.com/content/6/1/15. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)