The exact mechanism allowing the derepression of polycomb target genes during cell differentiation remains unclear.
Catherine Creppe, Anna Palau, Roberto Malinverni, Vanesa Valero, Marcus Buschbeck 2014, 'A Cbx8-containing polycomb complex facilitates the transition to gene activation duringES cell differentiation.', PLoS Geneticshttp://europepmc.org/articles/PMC4263398?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In most cases the resistant strains expressed higher cephalosporinase activity than the original strains, suggesting derepression of chromosomal β-lactamases.
Papaioannidou Paraskevi, Nitsas Vassilios, Mirtsou-Fidani Vassiliki 2009, 'Hydrolysis of cefazolin by enzymes produced by Pseudomonas aeruginosa after exposureto ceftazidime in vitro', Vojnosanitetski Pregledhttp://www.doiserbia.nb.rs/img/doi/0042-8450/2009/0042-84500910785P.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Microarray analyses indicated that many of these genes exhibited derepression after differentiation toward hepatocyte and cholangiocyte lineages.
Kengo Kanayama, Tetsuhiro Chiba, Motohiko Oshima, Hiroaki Kanzaki, Shuhei Koide, AtsunoriSaraya, Satoru Miyagi, Naoya Mimura, Yuko Kusakabe, Tomoko Saito, Sadahisa Ogasawara,Eiichiro Suzuki, Yoshihiko Ooka, Hitoshi Maruyama, Atsushi Iwama, Naoya Kato 2019, 'Genome-Wide Mapping of Bivalent Histone Modifications in Hepatic Stem/Progenitor Cells',Stem Cells Internationalhttp://dx.doi.org/10.1155/2019/9789240. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Because segmentation involves complex cross-talk between several signalling pathways, we analysed how rbpj derepression impacted these pathways.
Marie Cibois, Carole Gautier-Courteille, Laurent Kodjabachian, Luc Paillard 2013, 'A gene regulation network controlled by Celf1 protein–rbpj mRNA interaction in Xenopussomite segmentation', Biology Openhttp://bio.biologists.org/content/2/10/1078. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Recently, the derepression of different gene classes in l(3)mbt mutants was shown to be causal for transformation.
Karin Meier, Eve-Lyne Mathieu, Florian Finkernagel, L Maximilian Reuter, Maren Scharfe,Gunther Doehlemann, Michael Jarek, Alexander Brehm 2012, 'LINT, a novel dL(3)mbt-containing complex, represses malignant brain tumour signaturegenes.', PLoS Geneticshttp://europepmc.org/articles/PMC3342951?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)