Furthermore, treatment with combination therapy induced β-cell neogenesis from pancreatic duct-derived cells.
Ansarullah, Yan Lu, Martha Holstein, Brittany DeRuyter, Alex Rabinovitch, ZhiguangGuo 2013, 'Stimulating β-cell regeneration by combining a GPR119 agonist with a DPP-IV inhibitor.',PLoS ONEhttp://europepmc.org/articles/PMC3558424?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In addition, β-cell neogenesis was induced from pancreatic duct cells in the islet grafts.
Ansarullah, Colette Free, Jenica Christopherson, Quanhai Chen, Jie Gao, ChengyangLiu, Ali Naji, Alex Rabinovitch, Zhiguang Guo 2016, 'Activation of GPR119 Stimulates Human β-Cell Replication and Neogenesis in HumanizedMice with Functional Human Islets', Journal of Diabetes Researchhttp://dx.doi.org/10.1155/2016/1620821. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Pancreatic ductal epithelium cells are one of the important sources of the pancreatic islet β-cell neogenesis.
Nan Zhang, Di Gao, Yudan Liu, Sihan Ji, Lei Sha 2018, 'Effects of Neuropeptide Substance P on Proliferation and β-Cell Differentiation ofAdult Pancreatic Ductal Cells', Frontiers in Neurosciencehttps://www.frontiersin.org/article/10.3389/fnins.2018.00806/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Oxidative stress plays an important role in β cell neogenesis, proliferation, and survival under both physiological and pathophysiological conditions.
Jingjing Wang, Hongjun Wang 2017, 'Oxidative Stress in Pancreatic Beta Cell Regeneration', Oxidative Medicine and Cellular Longevityhttp://dx.doi.org/10.1155/2017/1930261. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We performed genetic lineage tracing experiments to evaluate the contribution of beta cell neogenesis in this model.
Imane Song, Oelfah Patel, Eddy Himpe, Christo J. F. Muller, Luc Bouwens 2015, 'Beta Cell Mass Restoration in Alloxan-Diabetic Mice Treated with EGF and Gastrin',PLOS ONE10.1371/journal.pone.0140148. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These findings might have important implications for the in vivo induction of duct-to-beta cell neogenesis in patients with beta-cell deficiency.
Benjamin Uzan, Florence Figeac, Bernard Portha, Jamileh Movassat 2009, 'Mechanisms of KGF mediated signaling in pancreatic duct cell proliferation and differentiation.',PLoS ONEhttp://europepmc.org/articles/PMC2649538?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In destructive inflammatory diseases, the regenerative ability of cartilaginous tissue proves to be inadequate for neogenesis of joints.
Marzhan Kaulambayeva, Galina Fedotovskikh, Anara Nurmukhambetova 2014, 'Application of Cellular Technologies to the Experimental Treatment of DestructiveInflammatory Arthropathies', Central Asian Journal of Global Healthhttp://cajgh.pitt.edu/ojs/index.php/cajgh/article/view/161. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Significantly higher improvement in cartilage neogenesis and recovery was observed in the treated group compared to the untreated control group.
Bei-ying Zhang, Bing-yun Wang, Shao-chuan Li, Dong-zhang Luo, Xiaoshu Zhan, Sheng-fengChen, Zhi-sheng Chen, Can-ying Liu, Hui-qin Ji, Yin-shan Bai, Dong-sheng Li, YangHe 2018, 'Evaluation of the Curative Effect of Umbilical Cord Mesenchymal Stem Cell Therapyfor Knee Arthritis in Dogs Using Imaging Technology', Stem Cells Internationalhttp://dx.doi.org/10.1155/2018/1983025. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)