Recent reports indicate that statins can cause nephrotoxicity.
R A Annigeri, R M Mani 2015, 'Acute interstitial nephritis due to statin and its class effect', Indian Journal of Nephrologyhttp://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2015;volume=25;issue=1;spage=54;epage=56;aulast=Annigeri. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, at high doses, it can induce hepatotoxicity and nephrotoxicity.
Fatih Mehmet Kandemir, Sefa Kucukler, Eyup Eldutar, Cuneyt Caglayan, İlhami Gülçin 2017, 'Chrysin Protects Rat Kidney from Paracetamol-Induced Oxidative Stress, Inflammation,Apoptosis, and Autophagy: A Multi-Biomarker Approach', Scientia Pharmaceuticahttp://www.mdpi.com/2218-0532/85/1/4. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
It has many similarities to human cisplatin nephrotoxicity, which are mentioned in the paper.
Martina Perše, Željka Večerić-Haler 2018, 'Cisplatin-Induced Rodent Model of Kidney Injury: Characteristics and Challenges',BioMed Research Internationalhttp://dx.doi.org/10.1155/2018/1462802. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
It was reported that genetic deficiency of caspase-1 prevented cisplatin-induced nephrotoxicity.
Jung-Yeon Kim, Jae-Hyung Park, Kiryeong Kim, Jungmin Jo, Jaechan Leem, Kwan-Kyu Park 2018, 'Pharmacological Inhibition of Caspase-1 Ameliorates Cisplatin-Induced Nephrotoxicitythrough Suppression of Apoptosis, Oxidative Stress, and Inflammation in Mice', Mediators of Inflammationhttp://dx.doi.org/10.1155/2018/6571676. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
There was no case of nephrotoxicity or ototoxicity among our patients.
Clélia Maria Erwenne, Célia Beatriz Gianotti Antonelli, uardo Ferrari Marback, PauloEduardo Novaes 2003, 'Tratamento conservador em retinoblastoma intra-ocular Conservative treatment for intraocularretinoblastoma', Arquivos Brasileiros de Oftalmologiahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492003000700011. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Ototoxicity developed in 32%, and nephrotoxicity in 15%.
Danielle B Cohen, Geriant Davies, Wakisa Malwafu, Helen Mangochi, Elizabeth Joekes,Simon Greenwood, Liz Corbett, S Bertel Squire 2019, 'Poor outcomes in recurrent tuberculosis: More than just drug resistance?', PLoS ONEhttp://europepmc.org/articles/PMC6502344?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Cisplatin-induced nephrotoxicity limits its use in many cancer patients.
Kamyar Zahedi, Sharon Barone, Christina Destefano-Shields, Marybeth Brooks, TracyMurray-Stewart, Matthew Dunworth, Weimin Li, Joanne R. Doherty, Mark A. Hall, RogerD. Smith, John L. Cleveland, Robert A. Casero, Manoocher Soleimani 2017, 'Activation of endoplasmic reticulum stress response by enhanced polyamine catabolismis important in the mediation of cisplatin-induced acute kidney injury', PLOS ONE10.1371/journal.pone.0184570. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The known oto- and nephrotoxicity associated with aminoglycosides preclude long-term use as readthrough agents.
Westley J. Friesen, Briana Johnson, Jairo Sierra, Jin Zhuo, Priya Vazirani, XiaojiaoXue, Yuki Tomizawa, Ramil Baiazitov, Christie Morrill, Hongyu Ren, Suresh Babu, Young-ChoonMoon, Art Branstrom, Anna Mollin, Jean Hedrick, Josephine Sheedy, Gary Elfring, MarlaWeetall, Joseph M. Colacino, Ellen M. Welch, Stuart W. Peltz 2018, 'The minor gentamicin complex component, X2, is a potent premature stop codon readthroughmolecule with therapeutic potential', PLOS ONE10.1371/journal.pone.0206158. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The mechanisms of gentamicin-induced nephrotoxicity are principally from renal inflammation and oxidative stress.
Krit Jaikumkao, Anchalee Pongchaidecha, La-ongdao Thongnak, Keerati Wanchai, PhatchawanArjinajarn, Varanuj Chatsudthipong, Nipon Chattipakorn, Anusorn Lungkaphin 2016, 'Amelioration of Renal Inflammation, Endoplasmic Reticulum Stress and Apoptosis Underliesthe Protective Effect of Low Dosage of Atorvastatin in Gentamicin-Induced Nephrotoxicity',PLOS ONE10.1371/journal.pone.0164528. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Suppression of autophagosome formation increased colistin induced nephrotoxicity.
Sun-hyo Lee, Jin-sun Kim, Kameswaran Ravichandran, Hyo-Wook Gil, Ho-yeon Song, Sae-yongHong 2015, 'P-Glycoprotein Induction Ameliorates Colistin Induced Nephrotoxicity in Cultured HumanProximal Tubular Cells', PLOS ONE10.1371/journal.pone.0136075. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)