having two substituent atoms, groups, or radicals in a molecule
disubstituted in American English
(daiˈsʌbstɪˌtuːtɪd, -ˌtjuː-)
adjective
Chemistry
containing two substituents
Word origin
[1885–90; di-1 + substituted]This word is first recorded in the period 1885–90. Other words that entered Englishat around the same time include: classified, reactor, sensitization, upsweep, zoomdi- is a prefix occurring in loanwords from Greek, where it meant “two,” “twice,” “double”(diphthong). On this model, di- is freely used in the formation of compound words (dicotyledon; dipolar) and in chemical terms (diatomic; disulfide)
Examples of 'disubstituted' in a sentence
disubstituted
A series of 2,4-disubstituted quinazoline derivatives were designed and synthesized.
Guangjin Yu, Zeng Li, Liang Tang, Qiru Xiong 2014, 'Synthesis and Evaluation of 2,4-Disubstituted Quinazoline Derivatives with PotentAnti-Angiogenesis Activities', Moleculeshttp://www.mdpi.com/1420-3049/19/7/8916. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Alternatively, oxidation of the intermediates produces 3,5-disubstituted pyrrole-2-carbonitriles.
Murat Kucukdisli, Dorota Ferenc, Marcel Heinz, Christine Wiebe, Till Opatz 2014, 'Simple two-step synthesis of 2,4-disubstituted pyrroles and 3,5-disubstituted pyrrole-2-carbonitrilesfrom enones', Beilstein Journal of Organic Chemistryhttps://doi.org/10.3762/bjoc.10.44. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Fourteen synthetic 1, 4-disubstituted piperidines with simple molecular structures were evaluated in this study.
Moses N. Ngemenya, Grace Ntube Abwenzoh, Hermia Nalova Ikome, Denis Zofou, FideleNtie-Kang, Simon M. N. Efange 2018, 'Structurally simple synthetic 1, 4-disubstituted piperidines with high selectivityfor resistant Plasmodium falciparum', BMC Pharmacology and Toxicologyhttp://link.springer.com/article/10.1186/s40360-018-0233-2. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Disubstituted oxazol-5-one and pyrazoles are known to exhibit various biological activities.
N. D. Argade, B. K. Kalrale, C. H. Gill 2008, 'Microwave Assisted Improved Method for the Synthesis of Pyrazole Containing 2,4,-DisubstitutedOxazole-5-one and their Antimicrobial Activity', E-Journal of Chemistryhttp://dx.doi.org/10.1155/2008/265131. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The results revealed that 1,3- disubstituted urea derivatives showed good biofilm inhibition.
Gurmeet eKaur, Balamurugan eP, Uma Maheswari eC, Anitha eA., S. Adline ePrincy 2016, 'Combinatorial effects of aromatic 1,3 – disubstituted ureas and fluoride on in vitroinhibition of Streptococcus mutans biofilm formation', Frontiers in Microbiologyhttp://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00861/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We herein describe the preparation and characterisation of new 2,4-disubstituted oxo-, thiooxo-, and selenooxophospholes.
Guillaume Bousrez, Emmanuel Nicolas, Agathe Martinez, Sylviane Chevreux, Florian Jaroschik 2019, '[4+2] versus [2+2] Homodimerization in P(V) Derivatives of 2,4-Disubstituted Phospholes',Heteroatom Chemistryhttp://dx.doi.org/10.1155/2019/2596405. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These reactions afforded disubstituted piperidine derivatives with high diastereoselectivities and good toexcellent yields.
Koichi Mitsudo, Junya Yamamoto, Tomoya Akagi, Atsuhiro Yamashita, Masahiro Haisa,Kazuki Yoshioka, Hiroki Mandai, Koji Ueoka, Christian Hempel, Jun-ichi Yoshida, SeijiSuga 2018, 'Stereoselective nucleophilic addition reactions to cyclic N-acyliminium ions usingthe indirect cation pool method: Elucidation of stereoselectivity by spectroscopicconformational analysis and DFT calculations', Beilstein Journal of Organic Chemistryhttps://doi.org/10.3762/bjoc.14.100. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The schemes of synthesis of 1,4-disubstituted-1,2,3-butatrienes are presented.
V.M. Dembitsky, G.A. Tolstikov, M. Srebnik 2003, 'Boranes in Organic Chemistry 3. О±-, ОІ- and Оі-Haloalkylboranes: The PerspectiveVehicles for Organic Synthesis', Eurasian Chemico-Technological Journal http://ect-journal.kz/index.php/ectj/article/view/425. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
A series of 1,4-disubstituted-3,4-dihydroisoquinoline derivatives designed as tubulinpolymerization inhibitors were synthesized.
Ling Zhang, Yunlong Song, Jingjing Huang, Jia Liu, Wenwen Zhu, Youjun Zhou, JiaguoLv, Canhui Zheng, Ju Zhu 2015, 'Design, Synthesis and Biological Evaluation of 1,4-Disubstituted-3,4-dihydroisoquinolineCompounds as New Tubulin Polymerization Inhibitors', International Journal of Molecular Scienceshttp://www.mdpi.com/1422-0067/16/5/10173. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)