The results contradict proposals that dopamine has direct anti-nociceptive effects in acute experimental pain.
Susanne Becker, Marta Ceko, Mytsumi Louis-Foster, Nathaniel M Elfassy, Marco Leyton,Yoram Shir, Petra Schweinhardt 2013, 'Dopamine and pain sensitivity: neither sulpiride nor acute phenylalanine and tyrosinedepletion have effects on thermal pain sensations in healthy volunteers.', PLoS ONEhttp://europepmc.org/articles/PMC3827462?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Physiological (nociceptive) pain has protective value for an organism by promoting survival in life-threatening conditions.
Sonja L. Joksimovic, Douglas F. Covey, Douglas F. Covey, Vesna Jevtovic-Todorovic,Slobodan M. Todorovic, Slobodan M. Todorovic 2018, 'Neurosteroids in Pain Management: A New Perspective on an Old Player', Frontiers in Pharmacologyhttps://www.frontiersin.org/article/10.3389/fphar.2018.01127/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Nociceptive stimuli cause mast cell degranulation and the release of substances contained in the granules.
Guido Orlandini 2011, 'Glia, mast cells and related: new therapeutic perspectives?', Pathoshttp://www.pathos-journal.com/page_44.html. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Nociceptive signs were observed continuously and registered on-line each minute.
Marzieh Jahanbani, Sima Nasri, Firouz Ghaderi Pakdel, Ulker Cankurt, Parviz Shahabi,Sanaz Amirabadi, Somayyeh Naderi, Mostafa Ashrafi Osalou 2014, 'The Effect of Acute Intra Locus Coeruleus (LC) Microinfusion of Bupropion on Formalin-InducedPain Behavior in Rat', Basic and Clinical Neurosciencehttp://bcn.iums.ac.ir/browse.php?a_code=A-10-1-193&slc_lang=en&sid=1. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We hypothesised that curcumin alleviates lumbar radiculopathy by attenuating neuroinflammation, oxidative stress and nociceptive factors.
L Xiao, M Ding, A Fernandez, P Zhao, L Jin, X Li 2017, 'Curcumin alleviates lumbar radiculopathy by reducing neuroinflammation, oxidativestress and nociceptive factors', European Cells & Materialshttp://www.ecmjournal.org/papers/vol033/pdf/v033a21.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Recent reports indicate that resveratrol can modulate neuronal excitability, including nociceptive sensory transmission.
Mamoru Takeda, Shiori Takehana, Kenta Sekiguchi, Yoshiko Kubota, Yoshihito Shimazu 2016, 'Modulatory Mechanism of Nociceptive Neuronal Activity by Dietary Constituent Resveratrol',International Journal of Molecular Scienceshttp://www.mdpi.com/1422-0067/17/10/1702. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Katherine R. Stanford, Thomas E. Taylor-Clark 2018, 'Mitochondrial modulation-induced activation of vagal sensory neuronal subsets by antimycinA, but not CCCP or rotenone, correlates with mitochondrial superoxide production',PLOS ONE10.1371/journal.pone.0197106. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Immunohistochemical analysis of receptor distribution indicated that these receptors are widely expressed in nociceptive neurons.
Molliver Derek C, Malin Sacha A 2010, 'Gi- and Gq-coupled ADP (P2Y) receptors act in opposition to modulate nociceptive signalingand inflammatory pain behavior', Molecular Painhttp://www.molecularpain.com/content/6/1/21. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)