Studies aimed at understanding prebiotically pertinent nonenzymatic reactions have predominantly used activated nucleotides.
Niraja V. Bapat, Sudha Rajamani 2018, 'Templated replication (or lack thereof) under prebiotically pertinent conditions',Scientific Reportshttp://link.springer.com/article/10.1038/s41598-018-33157-9. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Prebiotic polymerization had to be a nonenzymatic, chemically driven process.
Chaitanya V. Mungi, Sudha Rajamani 2015, 'Characterization of RNA-Like Oligomers from Lipid-Assisted Nonenzymatic Synthesis:Implications for Origin of Informational Molecules on Early Earth', Lifehttp://www.mdpi.com/2075-1729/5/1/65. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This study aims to design polycations with tunable nonenzymatic degradability.
Mitsuru Naito, Yuta Otsu, Rimpei Kamegawa, Kotaro Hayashi, Satoshi Uchida, Hyun JinKim, Kanjiro Miyata 2019, 'Tunable nonenzymatic degradability of N-substituted polyaspartamide main chain byamine protonation and alkyl spacer length in side chains for enhanced messenger RNAtransfection efficiency', Science and Technology of Advanced Materialshttp://dx.doi.org/10.1080/14686996.2019.1569818. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
C-type lectin-like proteins were common nonenzymatic components in both species.
Syafiq Asnawi Zainal Abidin, Pathmanathan Rajadurai, Md Ezharul Hoque Chowdhury, MuhamadRusdi Ahmad Rusmili, Iekhsan Othman, Rakesh Naidu 2016, 'Proteomic Characterization and Comparison of Malaysian Tropidolaemus wagleri and Cryptelytropspurpureomaculatus Venom Using Shotgun-Proteomics', Toxinshttp://www.mdpi.com/2072-6651/8/10/299. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Antioxidants can be grouped into enzymatic and nonenzymatic antioxidants.
Zainol Haida, Mansor Hakiman 2019, 'A comprehensive review on the determination of enzymatic assay and nonenzymatic antioxidantactivities', Food Science & Nutritionhttps://doi.org/10.1002/fsn3.1012. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The composition was constructed as an electrode of nonenzymatic biosensor for glucose oxidation.
Zheng Li, Yong Zhang, Jiaye Ye, Meiqing Guo, Jing Chen, Weiyi Chen 2016, 'Nonenzymatic Glucose Biosensors Based on Silver Nanoparticles Deposited on TiO2 Nanotubes',Journal of Nanotechnologyhttp://dx.doi.org/10.1155/2016/9454830. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These nonenzymatic reactions have relevance to aging and age-related diseases.
Ohgi Takahashi, Ryota Kirikoshi, Noriyoshi Manabe 2014, 'Roles of Intramolecular and Intermolecular Hydrogen Bonding in a Three-Water-AssistedMechanism of Succinimide Formation from Aspartic Acid Residues', Moleculeshttp://www.mdpi.com/1420-3049/19/8/11440. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
It favors antioxidant enzymatic activities and nonenzymatic antioxidant capacity.
Israel Pérez-Torres, Juan Carlos Torres-Narváez, Verónica Guarner-Lans, Eulises Díaz-Díaz,Mario Perezpeña-Diazconti, Andrea Romero Palacios, Linaloe Manzano-Pech 2019, 'Myocardial Protection from Ischemia-Reperfusion Damage by the Antioxidant Effect ofHibiscus sabdariffa Linnaeus on Metabolic Syndrome Rats', Oxidative Medicine and Cellular Longevityhttp://dx.doi.org/10.1155/2019/1724194. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In the current study, we have tested the nonenzymatic glycation activities of ketohexoses,such as tagatose and psicose.
Dhananjay Yadav, Suk-Jeong Kim, Myung Ae Bae, Jae-Ryong Kim, Kyung-Hyun Cho 2018, 'The Ability of Different Ketohexoses to Alter Apo-A-I Structure and Function In Vitroand to Induce Hepatosteatosis, Oxidative Stress, and Impaired Plasma Lipid Profilein Hyperlipidemic Zebrafish', Oxidative Medicine and Cellular Longevityhttp://dx.doi.org/10.1155/2018/3124364. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Although being nonenzymatic, the enolization would need to be catalyzed to occur at a biologically relevant rate.
Ohgi Takahashi, Ryota Kirikoshi, Noriyoshi Manabe 2017, 'Racemization of Serine Residues Catalyzed by Dihydrogen Phosphate Ion: A ComputationalStudy', Catalystshttps://www.mdpi.com/2073-4344/7/12/363. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)