You use vicissitudes to refer to changes, especially unpleasant ones, that happen to someone or something at different times in their life or development.
[formal]
Whatever the vicissitudes of her past life, Jill now seems to have come through. [+ of]
vicissitudes in British English
(vɪˈsɪsɪtjuːdz)
plural noun
formal
variations in circumstance, fortune, character, etc, you have to deal with
Whatever the vicissitudes of her past life, Jill now seems to have come through.
Examples of 'vicissitudes' in a sentence
vicissitudes
Indeed, at one point he had seemed a likely candidate to become Prime Minister, but the vicissitudes of politics had intervened.
Harcourt, Palma DOUBLE DECEIT
As the senior pathologist at the disposal of the Security Services, he was no stranger to the many vicissitudes that human flesh is heir to.