He developed high-grade fever with cervical lymphadenopathy that was nonresponsive to routine line of management.
Khopkar Uday, Bhor Urmila 2008, 'Hodgkin′s lymphoma in a patient of psoriasis treated with long-term, low-dosemethotrexate therapy', Indian Journal of Dermatology, Venereology and Leprologyhttp://www.ijdvl.com/article.asp?issn=0378-6323;year=2008;volume=74;issue=4;spage=379;epage=382;aulast=Khopkar. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In contrast to motor disorders, pelvic organ autonomic dysfunctions are often nonresponsive to levodopa treatment.
Ryuji Sakakibara, Masahiko Kishi, Emina Ogawa, Fuyuki Tateno, Tomoyuki Uchiyama, TatsuyaYamamoto, Tomonori Yamanishi 2011, 'Bladder, Bowel, and Sexual Dysfunction in Parkinson's Disease', Parkinson's Diseasehttp://dx.doi.org/10.4061/2011/924605. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In nonresponsive cases, intravenous steroids show an objective response.
Kamat S 2004, 'A follow up study on interstitial alveolitis', Lung Indiahttp://www.lungindia.com/article.asp?issn=0970-2113;year=2004;volume=21;issue=4;spage=41;epage=45;aulast=Kamat. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These reactions were nonresponsive to topical steroids, and suture removal was required.
Hirano K, Tanaka H, Kato K, Araki-Sasaki K 2018, 'Graft rejection-like reactions in the early postoperative period after deep anteriorlamellar keratoplasty for keratoconus: a retrospective study', Clinical Ophthalmologyhttps://www.dovepress.com/graft-rejection-like-reactions-in-the-early-postoperative-period-after-peer-reviewed-article-OPTH. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In nonresponsive conservative treatment, myomectomy may be an option.
Shafiee M N, Nor Azlin MI, Arifuddin D 2012, 'A Successful Antenatal Myomectomy', Malaysian Family Physicianhttp://e-mfp.org/2012v7n2_3/Antenatal-Myomectomy.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
A liver transplant was then successfully performed despite the presence of a nonresponsive infection.
Marianna Mastroroberto, Sonia Berardi, Matteo Renzulli, Caterina Maggioli, Paolo Pianta,Antonio Daniele Pinna, Rita Golfieri, Claudia Sama 2012, 'Transcatheter Embolization for Giant Splenic Artery Aneurisms: Still an Open Question',Case Reports in Radiologyhttp://dx.doi.org/10.1155/2012/652469. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This has been successful in reducing side effects and in treating nonresponsive patients.
Françoso A, Simioni PU 2017, 'Immunotherapy for the treatment of colorectal tumors: focus on approved and in-clinical-trialmonoclonal antibodies', Drug Design, Development and Therapyhttps://www.dovepress.com/immunotherapy-for-the-treatment-of-colorectal-tumors-focus-on-approved-peer-reviewed-article-DDDT. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Our patient was found to be nonresponsive to imatinib therapy.
Javier De Luca-Johnson, Jose I. Ruades Ninfea, Lauren Pearson, Joanna Conant, RonaldBryant, Neil A. Zakai, Mary E. Tang 2016, 'Myeloid Neoplasms with t(5;12) and ETV6-ACSL6 Gene Fusion, Potential Mimickers ofMyeloid Neoplasm with PDGFRB Rearrangement: Case Report with Imatinib Therapy andReview of the Literature', Case Reports in Medicinehttp://dx.doi.org/10.1155/2016/8324791. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
There were 21 patients in the responsive group and 8 in the nonresponsive group.
Yang Jing-lan, Chen Shiau-yee, Hsieh Ching-Lin, Lin Jiu-jenq 2012, 'Effects and predictors of shoulder muscle massage for patients with posterior shouldertightness', BMC Musculoskeletal Disordershttp://www.biomedcentral.com/1471-2474/13/46. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
If the patient was nonresponsive to all approaches, oxygen alone was administered.
Yasaman Sadeghi, Meghdad Sedaghat, Mohammad Azad Majedi, Bahram Pakzad, Amir Ghaderi,Ahmad Raeisi 2019, 'Comparative Evaluation of Therapeutic Approaches to Central Sleep Apnea', Advanced Biomedical Researchhttp://www.advbiores.net/article.asp?issn=2277-9175;year=2019;volume=8;issue=1;spage=13;epage=13;aulast=Sadeghi. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)